The objective of this project is to translate the developmental ontology for neural tube closure, which was constructed in the LRI AIMT-5 project, into a computational model for predictive toxicology of neural tube defects. This represents a penultimate step for […]
This project aims at the generation and application of physiologically derived transport parameters in a PBPK model focusing on a more detailed description of substance uptake through the respiratory tract/via the inhalational route. This PBPK model is aimed to be […]
Chemical regulations require information as to whether a chemical is bioaccumulative. Steady-state bioconcentration factors (BCFs) in fish reflect the net result of the various chemical uptake versus loss processes and can be determined directly.
This project will carry out collaborative, mechanistically oriented research centered around the following three aims: Identify and quantify alterations in endogenous and xenobiotic-derived microbial metabolites; provide a basis to examine interspecies and interindividual differences in intestinal microbial metabolism; and develop […]
This project aims at understanding the consequences of chemical-induced changes in liver physiology on thyroid hormone balance and related adverse health effects. The project will focus on prenatal exposure and development of the foetus and new-born in the rat as […]
GETREAL will provide this information on the variability in chemical sensitivity and explore its consequences for risk assessment.
Microplastics research has grown substantially over the past years due to concerns with the public, the scientific community and environmentalist groups. They are often detected in environmental compartments but the hazards and risks they pose are debated and largely unknown.
Plastic pollution has become a major environmental concern among the public and government agencies, and in recent years the presence of microplastics in aquatic and terrestrial systems worldwide has received increasing attention.
The aim of this PROJECT PROPOSAL is to collate and update the existing global knowledge base on the available methods for the assessment of cationic polymers toxicity, fate properties as well as regarding their known descriptors used to develop Structure […]
Read-across is an old concept that is being increasingly utilized in chemical risk assessment. The basic premise for read-across is that compounds with similar chemical structure will have the same biological activity either because they are metabolized to a common […]
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