Projects

Intelligent testing, Microplastics

ECO56: UTOPIA: Development of a mUltimedia uniT world OPen-source model for mIcroplAstic

The main objective of UTOPIA is to develop an open-source unit world multimedia modeling platform to synthesize knowledge and understanding about the fate of microplastic in the environment. The UTOPIA project aims to deliver a general purpose open-source modeling platform […]

Acceptance of technology

AIMT11: Enhancing in vitro DNT Testing Strategy

Recently, the need for developmental neurotoxicity (DNT) testing has been moving into the focus of the scientific community including regulatory scientists. Several initiatives promoted by EFSA, the OECD, and the International STakeholder NETwork (ISTNET) for DNT highlighted the most urgent […]

Complex environments

ECO54: Developing a tiered modeling framework in support of risk assessment of chemical substances associated with mobility concerns

Persistent, mobile, and toxic (PMT) chemicals, including but not limited to plant protection products, pharmaceuticals, and personal care products, are perceived as an emerging threat to aquatic environments and drinking water quality [1]. Due to their high polarity and water […]

Human Health

C9: Mining the developmental toxicity genome in the zebrafish embryo test to develop a spatio-temporal map on morphogenesis and associated biomarker.

The LRI C9 project “zet-o-map” aims to develop better tools for the identification of teratogenic compounds. One of the most promising assays is the zebrafish embryo teratogenicity assay (ZETA).

Intelligent testing

ECO55: Assessing the Impact of Sample Collection on Microbial Population and Validity Criteria in the OECD 309 Surface Water Mineralisation Test

This project will provide improved guidance on surface water sample collection, storage and treatment including a scientifically defensible maximum range between water source sampling and experimental temperature and a suite of quantitative and qualitative tests that further demonstrate inoculum viability […]

C8 – Assessing the Repeatability of Metabolomics Within a Regulatory Context Through a Multi-laboratory Ring-trial

Background: Metabolomics has reached a critical point in determining its value to regulatory toxicology. Building on 20 years of metabolomics research in toxicology, during 2018-19 the first metabolomics data in a registration dossier was submitted to ECHA; metabolomics best-practice and […]

Human Health

B23 – Optimizing the benefit of REACH worker exposure assessments: ensuring meaningful health risk communication

The main objective of the project is to provide a substantial contribution to optimisation of information on (safe) use conditions, specifically in REACH.

Human Health

EMSG60 – Incidence trends of selected endocrine-related diseases and conditions in Europe and North America, and the contribution of changes in human reproduction

The first aim of the project is to investigate whether there has been an increase over time in the incidence of 14 diseases and conditions that may be associated with exposure to endocrine active substances.

Intelligent testing

ECO51 – SWiFT: Strengthening weight of evidence for FET data to replace acute fish toxicity

The use of fish embryo toxicity (FET) data for hazard assessments of chemicals, in place of acute fish toxicity (AFT) data, has long been the goal for many environmental scientists.

Complex environments

ECO53 – CC-ALT: A Chemical Categorisation Approach for Long- Range Transport Assessment

This project seeks to distinguish between four categories of chemicals that differ fundamentally in their LRT characteristics, and therefore require different, but complementary tools for LRTP assessment.