Projects

Intelligent testing

ECO51 – SWiFT: Strengthening weight of evidence for FET data to replace acute fish toxicity

The use of fish embryo toxicity (FET) data for hazard assessments of chemicals, in place of acute fish toxicity (AFT) data, has long been the goal for many environmental scientists.

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Complex environments

ECO53 – CC-ALT: A Chemical Categorisation Approach for Long- Range Transport Assessment

This project seeks to distinguish between four categories of chemicals that differ fundamentally in their LRT characteristics, and therefore require different, but complementary tools for LRTP assessment.

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Intelligent testing

B22 – TMEx-Complex: Tiered Methods for Quantifying Exposure to Complex Substances

Human exposure to chemicals is usually studied and understood in terms of the effect of a single pure chemical, but most humans are exposed to mixtures of chemicals. The project is focussed on determining how human exposure to chemicals is […]

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Complex environments

ECO52 – Bioavailability, complex substances and overall persistence (BCOP): three themes to deliver a step-change in persistence assessments

This project seeks to explore opportunities to improve weight-of-evidence approaches in persistence assessment by incorporating the latest scientific developments in bioavailability, complex substances and overall persistence.

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Human Health

B19.2 – Refinement of a framework for extrapolating of worker exposure measurement data

LRI B19.2 is an extension of Cefic-LRI B19 project: 'Extrapolating the Applicability of Worker Exposure Measurement Data'. The objective is to improve on the framework delivered in the previous B19 project, by 1) re-assessing the existing case studies in light […]

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Human Health

B15.3 – ECEL v3.0: Technical improvements and population of the integrated risk management measure (RMM) library

B15.3 is an extension of the “Cefic-LRI B15-2 project: Development of an integrated risk management measure library”. The main goal of this proposal is to upgrade ECEL v2.0 to ECEL v3.0 such that it is a well-designed, user-friendly tool with […]

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Intelligent testing

B18.2 – Incorporation of repeated dose study information for non-DNA-reactive carcinogens into the CPDB database and analysis of threshold values

This project is planned as extension of the project CEFIC LRI project B18, named “Database on Carcinogen Dose-response, including Information on DNA-reactivity, for TTC and beyond”, which is currently in its reporting phase. In this previous project, we updated the […]

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Human Health

B12.3 – Assessing the relevance of the dust contribution in consumer exposure to substances from consumer products and articles (DustEx extension)

Human exposure to semi-volatile organic compounds (SVOCs) present in materials is of great interest because of the large number of SVOCs used for different purposes in different materials; ranging from plasticizers in PVC to flame retardants in upholstery and clothing […]

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Intelligent testing

AIMT5.2 – A computational model for neural tube closure for in silico predictive toxicology of neural tube defects

The objective of this project is to translate the developmental ontology for neural tube closure, which was constructed in the LRI AIMT-5 project, into a computational model for predictive toxicology of neural tube defects. This represents a penultimate step for […]

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Human Health

B21 – In Vitro Data to Parameterise PBPK Models For Inhalation Exposure

This project aims at the generation and application of physiologically derived transport parameters in a PBPK model focusing on a more detailed description of substance uptake through the respiratory tract/via the inhalational route. This PBPK model is aimed to be […]

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