Principal Investigator
Prof J. Mark Parnis
Trent University
Canadian Environmental Modelling Centre (CEMC)
1600 West Bank Drive
Peterborough, Ontario, K9L 0G2
Canada
mparnis@trentu.ca
Tel. 1 (705) 748-1011 ext. 6224
Collaborators
Donald Mackay, Canadian Environmental Modelling Centre (CEMC), Trent University, Toronto, CA, dmackay@trentu.ca
Alena Celsie, Canadian Environmental Modelling Centre (CEMC), Trent University, Toronto, CA, alenacelsie@trentu.ca
Jon Arnot, ARC Arnot Research and Consulting, Inc. (ARC), Toronto, CA, jon.arnot@utoronto.ca
Trevor Brown, ARC Arnot Research and Consulting, Inc. (ARC), Toronto, CA, trevor.n.brown@gmail.com
Alessandro Sangion, ARC Arnot Research and Consulting, Inc. (ARC), Toronto, CA, alessandro.sangion@uninsubria.it
Li Li, ARC Arnot Research and Consulting, Inc. (ARC), Toronto, CA, environ.li@mail.utoronto.ca
James Armitage, ARC Arnot Research and Consulting, Inc. (ARC), Toronto, CA, james.armitage@utoronto.ca
Description
Human exposure to chemicals is usually studied and understood in terms of the effect of a single pure chemical, but most humans are exposed to mixtures of chemicals. The project is focused on determining how human exposure to chemicals is influenced by these chemicals being part of a commercial mixture. Such mixtures could be cleaning products, pharmaceuticals, persona-care products, and commercial chemical mixtures.
Since different chemicals interact in a number of ways, the project is seeking a set of rules that allow regulators and managers to determine what sort of mixture they are working with and how to best assess the exposure risk associated with it. The project will assess the quality and effectiveness of several state-of-the-art tools for predicting the properties of chemicals in mixtures. Ultimately, it will develop a prototype software tool that will allow for the estimation of human exposure from mixture components via inhalation and skin absorption.
