Cefic-lri Programme | European Chemical Industry Council

EMSG60 – Incidence trends of selected endocrine-related diseases and conditions in Europe and North America, and the contribution of changes in human reproduction

Principal Investigator

Dr Eva Negri
Università degli Studi di Milano
Department of Biomedical and Clinical Sciences
Polo Didattico
Vialba Via G. B. Grassi 74
20157 Milano
Tel. +39-347-8889634


Paolo Boffetta, University of Bologna, Department of Medical and Surgical Sciences, IT, paolo.boffetta@unibo.it

Carlo La Vecchia, University of Milan, Department of Clinical Sciences and Community Health, IT, carlo.lavecchia@unimi.it

Fabio Parazzini, University of Milan, Department of Clinical Sciences and Community Health, IT, fabio.parazzini@unimi.it


The first aim of the project is to investigate whether there has been an increase over time in the incidence of 14 diseases and conditions that may be associated with exposure to endocrine active substances.

These conditions are:

  • endometrial, breast, testicular and prostate cancer
  • semen quality
  • low birth weight and preterm births
  • early breast development and polycystic ovarian syndrome
  • hypospadias and cryptorchidism
  • autism spectrum disorders and attention deficit/hyperactivity disorder
  • diabetes and obesity

The second aim of the project is to systematically review the published literature on the association between reproductive factors and the 14 diseases and conditions. Reproductive factors have markedly changed over time, particularly in high-income countries (e.g. age at first birth, number of children, maternal obesity), and it is possible that these changes had an influence on the incidence of the conditions under study.

The third aim of the study uses the results from our systematic reviews (Aim #2) in order to evaluate how the changes over time in reproductive factors may have influenced the incidence trends of the 14 diseases and conditions under study (Aim #1).

Related Publications

Michela Dalmartello, Francesca Chiaffarino, Giovanna Esposito, Sonia Cipriani, Elena Ricci, Carlo La Vecchia, Fabio Parazzini, Luca Persani, Eva Negri. “A systematic review on maternal and perinatal factors influencing breast development”, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy, 2023.

Timeline: May 2020 > April 2022

LRI funding: € 247 000

Cefic-Lri Programme Responsible Care

Terms and Conditions of Use | Privacy Policy | Cookie Policy | Coockie Settings

© Copyright 2017 Cefic | European Chemical Industry Council. All rights reserved.