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PBPK/MEGen

MEGen (Model Equation Generator) software is a 'proof of concept' intuitive user interface for the rapid generation and analysis of PBPK models which was successfully developed by Cefic LRI in collaboration with HSL under project B3.7:Rapid Generation and Analysis of Physiologically-Based Pharmacokinetic Models (PBPK Model).

MEGen enables a user to describe physiology, biology and toxicology in order to output a set of mathematical equations that emulate the information supplied by the user and constitute a PBPK model. During this process, the software interrogates a built-in database, supplying pertinent data for use within the model. The resulting mathematics can be translated and imported into a number of commercial modelling packages where it may be visualised and exercised.

Another feature of the MEGen model building process is the provision of a transparent and auditable trail. MEGen provides a schematic diagram of a built model along with a corresponding table listing the value, units, source, origin and reference for each parameter specified.  The diagrams and tables can be exported directly into documents prepared in standard word processors. For an overall view of MEGen click here.

Since its launch in May 2007 MEGen has attracted 245 registered users from 40 countries representing regulatory agencies, industry and academia.

MEGen is freely available under the General Public Licence regulation at http://xnet.hsl.gov.uk/megen/.

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