Cefic-lri Programme | European Chemical Industry Council

BIOACCUMULATION ASSESSMENT TOOL (BAT): A Quantitative Weight of Evidence (QWOE) framework to aid bioaccumulation assessment

Understanding the behavior of chemicals in the environment is fundamental in risk assessment. The accumulation of chemical substances in living organisms is a complex process, and one of increasing interest to regulatory agencies. The Bioaccumulation Assessment Tool (BAT) facilitates the systematic and transparent integration of information in a consistent framework to inform bioaccumulation assessment decision-making.

The BAT is a user-friendly spreadsheet-based tool to guide the collection, generation, evaluation, and integration of various lines of evidence (LOE)* to aid bioaccumulation assessment decision-making for aquatic and terrestrial organisms.  The BAT provides a consistent Quantitative Weight of Evidence (QWOE) approach that includes critical evaluations of data confidence. It can provide guidance for integrated testing strategies should further information be necessary for decision-making.

Operating system

Windows. The BAT v.1.0 is freeware as implemented (coded) in Visual Basic for Applications (VBA) with the Graphical User Interface designed in Excel™.

User help

The BAT User Manual and Quick Start Guide are embedded as pdfs within the Excel file. This Quick Start Guide can be considered to expedite the use of the BAT; however, all BAT users are strongly encouraged to read the User Manual before using the tool.

Check this recent presentation of the BAT system given to stakeholders.

 

Download BAT Ver.1.0 here

 

References

Armitage JM, Toose L, Embry M, Foster KL, Hughes L, Arnot JA. 2018. The Bioaccumulation Assessment Tool (BAT) Version 1.0. Developed by ARC Arnot Research and Consulting Inc., Toronto, ON, Canada

BAT Ver.1.0 was publicly released October 2018.

 

* Chemicals are being assessed for bioaccumulation (B) potential using various LOEs, methods, metrics and classification criteria.  In vivo laboratory-based lines of evidence include the bioconcentration factor (BCF) and biomagnification factor (BMF).  In vitro biotransformation rate data (S9, hepatocytes) can also be applied for “B” assessment using in vitro-in vivo extrapolation (IVIVE) methods.  Field-based LOEs include the BMF, bioaccumulation factor (BAF), and the Trophic Magnification Factor (TMF). In silico LOEs include quantitative structure-activity relationships (QSARs) for the BCF and the biotransformation rate constant (kB) and mass balance bioaccumulation (toxicokinetic) models.

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