Principal Investigator
Collaborators
Description
The overall objective of the project is to determine whether model organisms with genetically sensitized signal transduction pathways can be used as predictors of mammalian developmental toxicity.
Specific objectives:
– Evaluate the effect of model developmental toxicants on the morphological development of a limited number of strains of Drosophila, C. elegans, and zebrafish that are sensitized for specific signal transduction pathways. Results using the sensitized strains will be compared either with wild-type organisms or with organisms heterozygous for the sensitizing mutations.
– Evaluate the effect of model developmental toxicants on the biochemical function of key signal transduction pathways to further support the biological relevance, at a molecular level, for the prediction of mammalian developmental toxicity.
– Determine whether human-relevant metabolizing systems can be incorporated into the sensitized screens.
Related Publications
Research project summary:
Evaluation of Signal Transduction Pathways in Model Organisms as Critical Mediators of Developmental Toxicity by G. Daston, J. Naciff, G. Overmann, Y. Shan, X. Wang, S. Patel and Jing Lu
Poster:
Signal Transduction Pathways: Potential Foundation for Developmental Toxicity Alternatives by George Daston
