Cefic-lri Programme | European Chemical Industry Council

B1.1-FRAU: Identification of Structure Activity Relationships Alerts for Substances With Low NOELs (REPDOSE)

Principal Investigator

Dr. Inge Mangelsdorf
Fraunhofer – Institute of Toxicology and Aerosol Research
Nikolai-Fuchs-Str. 1
30625 Hannover
Tel: +49 511 5350 303
Fax: +49 511 5350-335


The toxicological data profiles of many of the more than 100,000 substances included in the EINECS are incomplete. Scientific tools are needed to minimize test requirements and to prioritise research needs. Here consideration of Structure Activity Relationships (SAR) could be of valuable help. Research objective of the present project was to create a new database which should help to classify chemicals into combinations of chemical functional groups/categories and toxicological endpoints i.e. target organs.

Related Publications

A Bitsch, S Jacobi, C Melber, U Wahnschaffe, N Simetska, I Mangelsdorf, REPDOSE: A database on repeated dose toxicity studies of commercial chemicals. A multifunctional toolRegulatory Toxicology and Pharmacology 2006, 46, 202-210.

Timeline: October 2000 > September 2002

LRI funding: €105,563

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