Principal Investigator
Dr. Jody Schinkel – TNO (Netherlands Organisation for Applied Scientific Research)
Collaborators
Nicholas Warren– UK Health and Safety Executive (UK HSE)
Urs Schlüter– Federal instiute of Occupational Safety and Health (BAuA)
Description
In 2018 the dermal Advanced REACH Tool (dART) was developed, calibrated and published (Goede 2018, McNally 2019), initiated by the Health and Safety Executive (UK) and the Dutch Ministry of Social Affairs and Employment. The dART has been developed as an extension to the ART model and involves a new mechanistic Tier 2 exposure model for estimating dermal exposure to the hands to low volatile liquid products (Vp ≤10 Pa at 20 ⁰C) and solids in liquids. The tool incorporates elements of the ART model for estimating dermal contamination by aerosol deposition (one of the three routes in the dermal exposure model). The dermal mechanistic model framework is based upon that of ART and follows the same source-receptor model with principal modifying factors along the source-receptor pathways (McNally 2019).
The current dART model has only been calibrated and not yet been validated with dermal measurements and is therefore not yet publicly available (only as a demo version on the TNO DIAMONDS IT platform). Thus the project has the following objectives:
- Scientific improvement of the estimate to mg/kg bw/day to ensure regulatory compliance, considering loading saturation, retention, and removal processes
- Collection of existing dermal measurement data
- Validation and recalibration of the dART model with dermal exposure measurement data
