Cefic-lri Programme | European Chemical Industry Council

B5-CERTH: Realistic estimation of exposure to substances from multiple sources (TAGS)

Principal Investigator

Prof. Anastasios Karabelas
Chemical Process Engineering Institute
P.O. Box 60361
6th km Charilaou-Thermi Road
GR 57001 Thessaloniki
Tel: +30 2310 498181
Fax: +30 2310 498189


Dr. Alberto Gotti, Dr. Spyros Karakitsios, Dr. Periklis Kontoroupis, Ir Ermioni Solomou, Centre for Research and Technology Hellas – Chemical Process Engineering Institute
Drs. John Cherrie, Fintan Hurley, Martie van Tongeren, Prof. Sean Semple, Institute for Occupational Medicine (IOM)
Ir Christa Cornelis, Dr. Roel Smolders, ir. Rudi Torfs, VITO/Unit of Environmental Risk and Health


Exposure to chemical agents originates either from environmental contamination (air, water), or from consumer products (food contact materials, construction materials, cosmetics, clothes, etc.) through multiple routes, namely inhalation, ingestion and dermal contact. Aggregate exposure, i.e. the quantitative exposure assessment to a single agent from all potential exposure pathways (the physical course taken by an agent as it moves from a source to a point of contact with a person) and the related exposure routes, raises specific issues that need to be addressed.

The objective of the project is thus the development of a tiered approach to aggregate exposure assessment and the compilation of a computational platform, able to perform quantitative aggregate exposure assessments for environmental and consumer products following a full chain approach (including emission-migration, media concentrations, exposure and internal dosimetry). The use of biomarkers to verify model predictions, to reconstruct population exposure and allocate to apportion exposure to sources (reverse modeling) will constitute a part of the tiered approach and the accompanying guidance. The tiered approach will guide the user through the preparation of the exposure assessment.

Related Publications


A novel tiered approach to aggregate exposure assessment of chemicals in articles and the environment by D. Sarigiannis, S. Karakitsios, C. Cornelis, M. Van Tongeren, K. De Brouwere, J. Cherrie, R. Torfs, A. Gotti and A.J. Karabelas

Application of the TAGS tiered approach for aggregate exposure assessment to the flame retardant BDE-209 by C. Cornelis, K. De Brouwere, D. Sarigiannis and M. Van Tongeren

Timeline: January 2010 > March 2012

LRI funding: €399,903

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