ECO14bis-UNT: Alternative methodology for standard laboratory fish bioconcentration tests

Description

The overall goal of this project is to recommend a scientifically sound and defensible minimalized experimental design for fish bioconcentration measurement.  This experimental design will meet the “spirit” of the OECD 305 protocol producing key regulatory data, but ideally will require less time, money and fewer animals to conduct. Two experimental approaches will be evaluated during this project; the first approach is based on sampling of fish only during the depuration period of a study, whereas the second proposed approach is based on sampling fish during the uptake phase of a study.