Cefic-lri Programme | European Chemical Industry Council

EMSG22: Endocrine Disruption in the Aquatic Environment; Laboratory Investigation of Endocrine-Active Chemicals

Principal Investigator

Prof. John Sumpter
Brunel University
UK – UB8 3PH
Tel: +44 1895 27 20 89
Fax: +44 1895 20 30 99


Dr. Ludwig Karbe – Universität Hamburg
LRI Monitor:Prof. Dr. Franz Nader — VCI


Laboratory studies are being conducted in which fish are exposed to defined concentrations of known chemicals. Natural steroids, synthetic steroids and xenoestrogens will be assessed. The choice of test chemicals will depend on field studies in the UK and Germany, which run more or less in parallel with the laboratory studies. This will resolve the question of whether we should be more concerned about the presence of natural and synthetic steroids or xenoestrogens in the environment.

Related Publications

Hecker M. Natural variability of endocrine functions and their modulation by anthropogenic influences. PhD Thesis, University of Hamburg, 2001. Johnson AC and Sumpter JP. Removal of endocrine-disrupting chemicals in activated sludge treatment works. Environmental Science & Technology : Vol 35, Issue 24, 4697 – 4703, 2001. Harris, C.A., Santos, E.M., Janbakhsh, A., Pottinger, T.G., Tyler, C.R. and Sumpter J.P. 2001. Nonylphenol affects gonadotrophin levels in the pituitary gland and plasma of female rainbow trout. Environmental Science and Technology : Vol. 35, Issue 24, 2909-2916, 2001. Hecker, M., Tyler, C.R., Hoffman, M., Maddix, S., and Karbe, L. Plasma biomarkers in fish provide evidence for endocrine modulation in the Elbe River, Germany. Environmental Science and Technology : Vol. 36, Issue 11, 2311-231, 2002.

LRI funding: €302,500

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