Cefic-lri Programme | European Chemical Industry Council

EMSG28: Development, Validation and Application of in Vitro and in Vivo Test Systems for Non-Oestrogenic Endocrine Disrupting Chemicals in Wildlife

Principal Investigator

Dr. A.J. Murk
University of Wageningen
Section Toxicology
PO Box 8000
NL-6700 EA Wageningen, The Netherlands
Tel: +31 317 483233
Fax: +31 317 484931


LRI Monitor: Dr. Chris de Rooij – Solvay


The project will provide information on effective in vitro (T-screen & Keratonisation Assay) and in vivo assays (metamorphosis, migration and prolonged FETAX-assay) for alterations of thyroid and retinoid dependent processes. It will bridge the gap between the in vitro and in vivo assays, and the effects seen in the field on the population level. To achieve this, challenge experiments (choosing relevant stresses for the endocrine effects observed) with realistically exposed amphibia will be conducted. The Project is part of the Dutch National Investigation into Oestrogenic Compounds (LOES) programme. LRI Funding: €322,000 (Co-sponsored by the Dutch Government)

Related Publications

Merijn Schriks, Arno (A.C.) Gutleb, Hans (J.H.J.) Van den Berg, Tinka (A.J.) Murk. Thyroidogenic potency of compounds determined with the T-screen assay. Poster presentation at SETAC Europe 12th Annual Meeting. 12-16 May 2002. Vienna Austria. Challenges in Environmental Risk Assessment and Modelling: Linking Basic and Applied Research. Abstract nr 18-19.

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