Principal Investigator
Dr Elard Jacob
BASF
elard.jacob@basf-ag.de
Collaborators
Dr Remi Bars, Bayer CropScience, remi.Bars@bayercropscience.com
Dr Alexius Freyberger, Bayer HealthCare, alexius.freyberger.af@bayer-ag.de
Dr Jim Freeman, ExxonMobil, jim.freeman@exxonmobil.com
Dr John Ashby, Syngenta CTL UK, john.ashby@syngenta.com
Description
The objective of this project was the evaluation and validation of the uterotrophic assay as part of the official OECD validation of this test method. This uterotrophic bioassay is intended to identify the in vivo activity of compounds that are suspected agonists or antagonists of estrogen. The effect of selected chemicals were measured through variation in weight of the uterus in immature and ovariectomised female rats. Information from this assay could be used to help prioritize positive compounds for further definitive testing for risk assessment purposes.
Related Publications
Publications:
J Kanno, L Onyon, J Haseman, P Fenner-Crisp, J Ashby, W Owens, The OECD Program to Validate the Rat Uterotrophic Bioassay to Screen Compounds for in Vivo Estrogenic Responses: Phase 1, Environ Health Perspect. 2001 Aug; 109(8): 785–794.
W Owens, HBWM Koíter. The OECD Program to Validate the Rat Uterotrophic Bioassay: An Overview. Environ Health Perspect. 2003 Sep; 111(12): 1527–1529.
J Kanno, L Onyon, S Peddada, J Ashby, E Jacob, W Owens. The OECD Program to Validate the Rat Uterotrophic Bioassay. Phase 2: Dose-Response Studies. Environ Health Perspect. 2003, 111, 1530-1549.
J Kanno, L Onyon, S Peddada, J Ashby, E Jacob, W Owens, The OECD Program to Validate the Rat Uterotrophic Bioassay. Phase 2: Coded Single-Dose Studies. Environ Health Perspect. 2003 Sep; 111(12): 1550–1558.
W Owens, J Ashby, J Odum, L Onyon, The OECD Program to Validate the Rat Uterotrophic Bioassay. Phase 2: Dietary Phytoestrogen Analyses. Environ Health Perspect. 2003 Sep; 111(12): 1559–1567.
