Cefic-lri Programme | European Chemical Industry Council

EMSG47-WCA: Support a tiered approach to evaluate endocrine effects in aquatic organisms

Principal Investigator

Dr. Mark Crane
23 London Street, Faringdon
Oxfordshire, SN7 7AG
United Kingdom
Tel: +44 (0)1367 244311
Fax: +44 (0)1367 244311


Prof. Peter Matthlessen and John Fawell MBE, Watts & Crane Associates, UK


The specific objectives of the project are:

– Development of a ”Threshold of Toxicological Concern (TTC)” concept for ecotoxicology that is analogous to the mammalian approach. Potency, environmental fate and exposure to a substance should be considered to establish environmental ”negligible risk” levels.

– Comparison of modes of action covered by, and sensitivity of, proposed test methods for assessing chemical endocrine activity.

– Investigations into control variability of fish reproduction to determine what change is clearly an adverse biological effect.

Timeline: December 2007 > November 2008

LRI funding: € 188.500

Cefic-Lri Programme Responsible Care

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