Cefic-lri Programme | European Chemical Industry Council

LRI-B20 – Experimental assessment of inhalation and dermal exposure to chemicals during industrial and professional activities


Lower tier exposure assessment tools, like the ECETOC TRA, are widely used to assess dermal and inhalation exposure to chemicals in regulatory risk assessment for workers, consumers and the environment. These tools require limited information and are developed to generate conservative estimates of exposure. The reliability and representativeness of these tools needs to be established by comparing them with good quality exposure survey data or representative experimental data. Although the recent ETEAM project (BAuA, 2015) evaluated the TRA for some workplace settings (PROCs), its findings were not complete or conclusive and several substantive issues have subsequently been identified in the manner the ETEAM analyses were undertaken (Bachler et al, 2016). However, for many of the process categories that could be evaluated, the results indicate that both inhalation exposure estimates generated with the ECETOC TRA and other tier 1 tools are generally conservative. These findings have been further substantiated for the dermal exposure estimates of the TRA (Schinkel and Marquart, 2016). For some of the process categories though, results suggest that predictions may not be conservative enough to be reliably used in a Tier 1 assessment. For these activities, additional empirical data is needed to provide insight into why differences between model estimates and measured data are observed. Furthermore, any new data should provide guidance on changes that may need to be implemented in currently used exposure assessment tools. Alternatively, their applicability domain may need to be re-defined or restricted to ensure the exposure estimates that are generated using these tools are sufficiently conservative for all uses included in a risk assessment.

Principal Investigator

Dr. Wouter Fransman

TNO -  Netherlands Organisation for Applied Scientific Research
Utrechtseweg 48, 3700 AJ Zeist, NL
Tel. +31 (0)88 866 17 33
E-mail: wouter.fransman@tno.nl


Dr. K. M. Kasiotis

PhD Chemist Associate Researcher
Benaki Phytopathological Institute, Laboratory of Pesticides Toxicology
8 Stefanou Delta Street, Kifissia, Athens, 14561
E-mail: K.Kasiotis@bpi.gr
Tel. +30210 8180357, +30 6936509863


The purpose of this project is to generate inhalation and dermal exposure data that can be used to evaluate the ECETOC TRA worker exposure estimates for key industrial and professional uses of chemicals (including formulated products). The scope of these activities would be expected to cover those where insufficient data were identified by the ETEAM to yield conclusions (such as PROCs 3, 4 (solids] and 10 [solids]) as well as those PROCs considered to potentially underestimate ‘true’ exposures. In addition, it would be expected to cover those common workplace situations not addressed by the ETEAM (such as PROCs 2 and 17). It is not intended that the project covers either industrial or professional spraying activities or those PROCs with limited application (e.g. PROCs 6, 12 and 18). It would be the expectation that the project addresses the exposure potential presented by both solids and liquids across the relevant fugacity range. The data should be sufficient to enable the evaluation of the findings from previous studies and provide additional insight into the performance of ECETOC TRA. It should also provide insight into the possible reasons for differences observed between the measured data and the model estimates generated with the ECETOC TRA.

It is expected that the majority of the data will be generated in experimental settings to obtain representative base concentration estimates for both inhalation and dermal exposure. The experiments should as much as possible reflect real life use situations. In the case of dermal exposure, a quantitative comparison of the hands will be expected, as well as a qualitative assessment of the extent to which significant exposure of other body surfaces may also be associated with the activity.


CEFIC is seeking to support the generation of inhalation and dermal exposure data that can be used to evaluate the ECETOC TRA worker exposure estimates for key industrial and professional uses of chemicals (including formulated products). The scope of these activities would be expected to cover those where insufficient data have been identified by previous studies, such as the ETEAM, as well as those TRA settings where ‘true’ exposures have been considered to be potential underestimates

This project will need to account for:

  • Previous work in related areas that has sought to identify and collect relevant and reliable measured workplace exposure data
  • The identification of appropriate scenarios that simulated to provide representative (inhalation and dermal) exposure data for the scenario/PROC
  • Undertaking a series of simulations with different forms of chemicals (volatility and dustiness)
  • Comparing the findings against the relevant TRA estimates to help identify areas of the TRA that may benefit from further refinement.
  • The final report shall contain an executive summary (2 pages max), a main part (max. 50 pages) and a detailed bibliography.
  • It is expected that the findings will be developed into at least one peer reviewed publication, following postering(s) and presentation(s) at suitable scientific conference(s).

Related links

Download here the full version of the RfP LRI-B20.

Timing: Start January 2018 - 18 months

LRI funding: € 175K

Cefic-Lri Programme Responsible Care

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