Cefic-lri Programme | European Chemical Industry Council

BCF – Bioconcentration Factor Database

The classical approach to derive bioconcentration values (using the OECD 305 bioconcentration test) is labour intensive, costly and requires a lot of test animals. BCF is a gold standard database which was developed from the Cefic LRI-ECO7 project “Development of a Reference Database: Bio-concentration Factors BCF”) with the collaboration of EURAS. In particular, the aim of the project was to identify non-bioaccumulative substances (BCF<1000).

BCF gold standard database is linked with the relational database AMBIT for further (Q)SAR and alternative testing development.

The investigated criteria refer to molecular descriptors that are inherent features of the molecule. The validity of the criteria was investigated using data from the fish BCF gold standard database in AMBIT: (1) average diameter and molecular weight, (2) maximum molecular length, (3) log Kow.


The BCF gold standard database is freely available at http://ambit.sourceforge.net/euras/.



Luhndstedt M. N., Schmallenberg M.M. (2007). Einfluss von Lipophilie und Molekülgrösse auf das Biokonzentrationspotential von Umweltchemikalien. Mitt Umweltchem Ökotox. 13 Jahgr.(3), 68-71.


Versonnen B., Iaccino F., Jeliazkova N., Arijs K., Comber M., Verdonck F., Vangheluwe M. The fish Bioconcentration Factor gold standard database: practical examples.

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