Dr. Alice Limonciel – Medical University of Innsbruck, Austria
French researcher Dr. Alice Limonciel was awarded the €100,000 LRI Innovative Science award, one of Europe’s largest research grants for early career scientists, at an award ceremony at Cefic’s 17th Annual Long-Range Initiative (LRI) Workshop in Brussels on November 18, 2015.
Dr. Limonciel’s winning research proposal is entitled “Establishment of thresholds of activation of stress responses pathways and ligand-activated receptors for chemical classification” and will investigate cellular responses to the acceleration of chronic kidney disease progression due to chemical exposure. The project aims to identify the genes involved in cellular stress response pathways, quantify these responses in parallel with markers of cellular dysfunction and deliver a new generation of quantitative tools based on gene expression to evaluate the hazard linked to chemical exposure for use in risk assessment strategies.
Alice Limonciel graduated from the engineer school Polytech’ Nice-Sophia (France) in 2005, where she studied pharmacology and toxicology. She completed her PhD in the Department of Physiology and Medical Physics of the Medical University of Innsbruck (Austria) in October 2013 under the supervision of Paul Jennings, with a focus on the characterisation of the molecular stress responses of cultured human renal proximal tubule cells exposed to industrial and pharmaceutical nephrotoxins. Dr. Limonciel is currently continuing this work on molecular mechanisms of nephrotoxicity as a Postdoctoral researcher in Dr. Jennings’ group, notably using the integration of multiple omic datasets such as transcriptomics, proteomics, metabolomics and epigenomics.