AMBIT is a new open software tool designed to support companies by facilitating high quality chemical safety prediction. It contributes to the safer use of chemicals and a reduction in testing and innovation cost by making it easier for companies to comply with regulations governing chemicals. Based on a ‘predictive toxicity model’, AMBIT tool applies the principles of read-across - a scientific method for predicting unknown properties of one chemical from known properties of similar chemicals - and categorisation.
The Cefic-supported ‘Long Range Research Initiative’ (LRI) programme responsible for developing the software has the contribution of the European Chemicals Agency (ECHA) through sharing non-confidential REACH data to industry. This data is now integrated in the software, and demonstrates the chemical industry’s strong track record in collaborating with governmental chemical safety stakeholders. ECHA has given the Cefic LRI project access to the entire (14570 substances) non-confidential REACH dataset.
The AMBIT system consists of a database and functional modules allowing a variety of flexible searches and mining of the data stored in the database. The AMBIT database stores more than 450.000 chemical structures and their identifiers such as CAS, Einecs, Inchi numbers. It also contains attributes such as molecular descriptors, experimental data together with test descriptions, literature references. The data, which is quality assured and organized in searchable templates, offers unique features on chemicals information (structure, data, text), including REACH applicable PBT and analogues assessment.
Users can search and access a wide range of existing information about a chemical, as well as securely upload data generated by their own company. This process makes the tool both unique and powerful, particularly for data-poor small and medium sized enterprises (SMEs).
Cefic-LRI AMBIT tool boasts an enhanced search functionality offering superior substance search requests formatted for all data export formats, including the REACH IUCLID format, which is practical for users. AMBIT is designed to enable the secure importation of external databases from several sources in an easy way.
The original AMBIT tool on which the upgrade is based, was developed earlier by Procter & Gamble and Idea Consult. The new revamped AMBIT tool has been developed by Clariant Corporate Product Stewardship - Global Toxicology & Ecotoxicology in a LRI-project context and in collaboration with IT programmer Idea Consult, under the LRI project name of EEM9.3-IC.
How to access AMBIT?
The AMBIT tool can be consulted online at http://ambitlri.ideaconsult.net/. Users who already registered before at the test server can use the same username and password to login.
The tool is freely available to Cefic member companies and the whole public.
How can users and companies learn how to use AMBIT?
In January 2016, Cefic-LRI organised a hands-on training workshop to familiarize the experts with the revamped AMBIT tool. The presentations and downloadable instruction videos, which enable potential users to quickly master the tool, are available here.
Upcoming workshops on AMBIT:
- 13-15 July 2016, Seoul, South Korea – 14th International Nanotech Symposium & Nano-Convergence Expo, NANO KOREA 2016.
The presentation slides can be found on the event page.
- 4-7 September 2016, Sevilla, Spain - 52nd European Congress of the European Societies of Toxicology, EUROTOX 2016.
Please find here the AMBIT poster which will be presented at the event.
Past workshops on AMBIT:
- 13-17 June 2016, Miami, Florida, USA – 17th International Conference on QSAR in Environmental and Health Sciences
- 15-16 June 2016, Awaji Island, Japan – Meeting the Global Challenge of Applying New Scientific Methods to Improve Environmental and Human Health Risk Assessments
- 19-20 April 2016, Helsinki, Finland – Topical Scientific Workshop – New Approach Methodologies in Regulatory Science