Print this page

ECO16-IRAS: Generate a validated CBR database and validate a CBR chronic toxicity range for narcotics

Principal Investigator

Dr. Joop L.M. Hermens
Utrecht University
PO Box 80177
3508 TD Utrecht
The Netherlands
Tel: +31-30-2535337
Fax: +31-30-2535077

Collaborators

Dr. Philipp Mayer, Aarhus University, Denmark
Dr. Lynn McCarty, L.S. McCarty Scientific Research & Consulting, Canada
Dr. Jon Arnot, affiliated with University of Toronto Scarborough, Canada
Dr. Don Mackay, Trent University, Canada

Description

The general objective of the research project is to generate greater confidence and acceptance for the application of CBBs in the scientific community and in regulatory contexts. A key element of this research will be to compare model predictions that provide mechanistic insights with new measured data. This work will improve the interpretation of new and existing toxicity data and facilitate and encourage the use of CBBs for risk assessment and environmental quality objectives. This work will also improve the ability of scientists and regulators to communicate to the public the toxicological significance of observed levels of chemicals in the environment.

The scientific objectives are:

– to collect Lethal Body Burden (LBB) and Critical Body Burden (CBB) data from databases (e.g., Jarvinen and Ankley 1999) and the more recent and current scientific literature and to make the compilation available in a user-friendly CBR-database;
– to develop a system for evaluating the quality of the LBB/CBB data and apply these methods to the database;
– to design and execute laboratory experiments to further test and evaluate the proposed CBB toxicity range for narcotics (2-8 mmol/kg).

Related Publications

Stephan A. van der Heijden et al. (2015).Determining High-Quality Critical Body Residues for Multiple Species and Chemicals by Applying Improved Experimental Design and Data Interpretation Concepts. Environmental Science and Technology. 49, 1879−1887

Mackay D. et al (2014). Relationships between exposure and dose in aquatic toxicity tests for organic chemicals. Environmental Toxicology and Chemistry. 33 (9):2038-2046.

McCarty L.S. (2012). Model validation in aquatic toxicity testing: Implications for regulatory practice. Regulatory Toxicology and Pharmacology. 63(1), 353-362.

Armitage J.M., Arnot J.A., Wania F. and Mackay D. (2013). Development and evaluation of a mechanistic bioconcentration model for ionogenic chemicals in fish. Environmental Toxicology and Chemistry. 32, 115-128.

Mackay D., Arnot J.A., Gobas F. and Powell D. (2013). Mathematical relationships between metrics of chemical bioaccumulation in fish. Environmental Toxicology and Chemistry. 32(7), 1459-1466.

McCarty L.S., Arnot J.A. and Mackay D. (2013). Evaluation of critical body residue data for acute narcosis in aquatic organism. Environmental Toxicology and Chemistry. 32(10).

McCarty L.S. (2013), Are we in the dark ages of environmental toxicology? Regulatory Toxicology and Pharmacology 67, 321-324.

Posters:

Quality Evaluation of Critical Body Residues for Baseline Neutral Narcosis by L.S. McCarty, J.A. Arnot and D. Mackay, SETAC Congress Berlin 2012

Model Validation in Acute Aquatic Toxicity Testing by L.S. McCarty, SETAC Congress 2012

Critical body residue validation for aquatic organisms exposed to chemicals causing toxicity by baseline narcosis by Joop L.M. Hermens, Jon A. Arnot, Stephan A. van der Heijden, Michiel T.O. Jonker, Don Mackay,
Philipp Mayer and Lynn S. McCarty

Critical body residue validation for aquatic organisms exposed to chemicals causing toxicity by baseline narcosis by Joop L.M. Hermens, Jon A. Arnot, Stephan A. van der Heijden, Michiel T.O. Jonker, Don Mackay,
Philipp Mayer and Lynn S. McCarty

 

Timeline: February 2010 > January 2013

LRI funding: €517,972

Top

© Copyright 2014 Cefic | European Chemical Industry Council. All rights reserved | Terms and Conditions of Use