Cefic-lri Programme | European Chemical Industry Council

ECO16 – IRAS: Generate a validated CBR database and validate a CBR chronic toxicity range for narcotics

Principal Investigator

Dr. Joop L.M. Hermens
Utrecht University
PO Box 80177
3508 TD Utrecht
The Netherlands
Tel: +31-30-2535337

Fax: +31-30-2535077

Collaborators

Dr. Philipp Mayer, Aarhus University, DK, phm@dmu.dk
Dr. Lynn McCarty, L.S. McCarty Scientific Research & Consulting, CA, lsmccarty@home.com
Dr. Jon Arnot, affiliated with University of Toronto Scarborough, CA, jon.arnot@utoronto.ca

Dr. Don Mackay, Trent University, CA, dmackay@trentu.ca

Description

The general objective of the research project is to generate greater confidence and acceptance for the application of CBBs in the scientific community and in regulatory contexts. A key element of this research will be to compare model predictions that provide mechanistic insights with new measured data. This work will improve the interpretation of new and existing toxicity data and facilitate and encourage the use of CBBs for risk assessment and environmental quality objectives. This work will also improve the ability of scientists and regulators to communicate to the public the toxicological significance of observed levels of chemicals in the environment.

The scientific objectives are:

– to collect Lethal Body Burden (LBB) and Critical Body Burden (CBB) data from databases (e.g., Jarvinen and Ankley 1999) and the more recent and current scientific literature and to make the compilation available in a user-friendly CBR-database;
– to develop a system for evaluating the quality of the LBB/CBB data and apply these methods to the database;

– to design and execute laboratory experiments to further test and evaluate the proposed CBB toxicity range for narcotics (2-8 mmol/kg).

Related Publications

Publications: 

McCarty LS.  Model validation in aquatic toxicity testing: Implications for regulatory practice. Regul Toxicol Pharmacol. 2012 Aug;63(3):353-62.

Armitage JM1, Arnot JA, Wania F, Mackay D. Development and evaluation of a mechanistic bioconcentration model for ionogenic chemicals in fish. Environ Toxicol Chem. 2013 Jan;32(1):115-28.

Mackay D, Arnot JA, Gobas FA, Powell DE. Mathematical relationships between metrics of chemical bioaccumulation in fish. Environ Toxicol Chem. 2013 Jul;32(7):1459-66.

McCarty LS1, Arnot JA, Mackay D. Evaluation of critical body residue data for acute narcosis in aquatic organism. Environ Toxicol Chem. 2013 Oct;32(10):2301-14.

McCarty LS. Are we in the dark ages of environmental toxicology? Regul Toxicol Pharmacol. 2013 Dec;67(3):321-4

Mackay D, McCarty LS, Arnot JA. Relationships between exposure and dose in aquatic toxicity tests for organic chemicals. Environ Toxicol Chem. 2014 Sep;33(9):2038-46.

van der Heijden SA, Hermens JL, Sinnige TL, Mayer P, Gilbert D, Jonker MT. Determining High-Quality Critical Body Residues for Multiple Species and Chemicals by Applying Improved Experimental Design and Data Interpretation Concepts. Environ Sci Technol. 2015 Feb 3;49(3):1879-87.

Posters:

J.L.M. Hermens, J.A. Arnot, S.A. van der Heijden, M.T.O. Jonker, D. Mackay, P. Mayer, L.S. McCarty. Critical body residue validation for aquatic organisms exposed to chemicals causing toxicity by baseline narcosis. SETAC Europe 21rst Annual Meeting, May 2011, Milano, Italy.

J.L.M. Hermens, J.A. Arnot, S.A. van der Heijden, M.T.O. Jonker, D. Mackay, P. Mayer, L.S. McCarty. Critical body residue validation for aquatic organisms exposed to chemicals causing toxicity by baseline narcosis. Cefic-LRI 13th Annual Meeting, November 2011, Brussels, Belgium.

L.S. McCarty, J.A. Arnot, D. Mackay. Quality Evaluation of Critical Body Residues for Baseline Neutral Narcosis. SETAC Europe 22nd Annual Meeting, May 2012, Berlin, Germany.

L.S. McCarty. Model Validation in Acute Aquatic Toxicity Testing. SETAC Europe 22nd Annual Meeting, May 2012, Berlin, Germany.

Timeline: February 2010 > January 2013

LRI funding: € 517 972

Cefic-Lri Programme Responsible Care

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