LRI Monitor: Dr Elard Jacob – BASF Ludwigshafen
OECD Test Guideline Validation: to provide a set of defined test chemicals for the OECD test methods development for endocrine active chemicals and to guarantee that test method validation under OECD leads to reliable results by always using the same (batch of) test chemicals. Test Guidelines Development for Assessment of endocrine activity in Mammals are the Uterotrophic assay, the Hershberger Assay and the Short Term Repeat Dose Assay (OECD TG407 with enhancements) to detect (anti-)estrogenic, (anti-)androgenic and (anti-)thyroid activity of industrial chemicals.
K Yamasaki, R Ohta, H Okuda, OECD validation of the Hershberger assay in Japan: Phase 3. Blind study using coded chemicals, Toxicology Letters 2006, 163, 121-129.