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EMSG34B: Validation of the OECD Protocol for the Rat Uterotrophic assay

Principal Investigator

Industry Co-ordinator: BASF - Dr Elard Jacob elard.jacob@basf-ag.de

Collaborators

Participating Industry Laboratories:
Bayer CropScience - Dr Remi Bars - Remi.Bars@bayercropscience.com
BASF - Dr Elard Jacob - elard.jacob@basf-ag.de
Bayer HealthCare - Dr Alexius Freyberger - alexius.freyberger.af@bayer-ag.de
ExxonMobil - Dr Jim Freeman - jim.freeman@exxonmobil.com
Syngenta CTL UK - Dr John Ashby - john.ashby@syngenta.com

Description

The objective of this project was the evaluation and validation of the uterotrophic assay as part of the official OECD validation of this test method. This uterotrophic bioassay is intended to identify the in vivo activity of compounds that are suspected agonists or antagonists of estrogen. The effect of selected chemicals were measured through variation in weight of the uterus in immature and ovariectomised female rats. Information from this assay could be used to help prioritize positive compounds for further definitive testing for risk assessment purposes.

Related Publications

W Owens, HBWM Koí«ter, The OECD Program to Validate the Rat Uterotrophic Bioassay: An Overview, Environmental Health Perspectives 2003, 111, 1527-1529.

J Kanno, L Onyon, S Peddada, J Ashby, E Jacob, W Owens, The OECD Program to Validate the Rat Uterotrophic Bioassay. Phase 2: Dose-Response Studies, Environmental Health Perspectives 2003, 111, 1530-1549.

J Kanno, L Onyon, S Peddada, J Ashby, E Jacob, W Owens, The OECD Program to Validate the Rat Uterotrophic Bioassay. Phase 2: Coded Single-Dose StudiesEnvironmental Health Perspectives 2003, 111, 1550-1558.

W Owens, J Ashby, J Odum, L Onyon, The OECD Program to Validate the Rat Uterotrophic Bioassay. Phase 2: Dietary Phytoestrogen Analyses, Environmental Health Perspectives 2003, 111, 1559-1567.

J Kanno, L Onyon, J Haseman, P Fenner-Crisp, J Ashby, W Owens, The OECD Program to Validate the Rat Uterotrophic Bioassay to Screen Compounds for in Vivo Estrogenic Responses: Phase 1, Environmental Health Perspectives 2001, 109, 785-794.

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