The objective of the project is to verify whether impairment of expression and/or function of the gap junctional connexins (elements of the gap junction structure; this structure facilitates “communication” between cells) could be implicated in human male reproductive disorders. An in vitro model system (immortalised Sertoli cells) will be used to verify the possible link of hormonal regulation of connexins with endocrine disruptors.
Defamie N, Mograbi B, Roger C, Cronier L, Malassine A, Brucker-Davis F, Fenichel P, Segretain D and Pointis G. Disruption of gap junctional intercellular communication by lindane is associated with aberrant localisation of connexion43 and zonula occludens-1 in 42GPA9 Sertoli cells. Carcinogenesis : Vol. 22, Issue 9, 1537-1542, September 2001.