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EMSG8: Are Connexins, the Gap Junctional Integral Proteins, Involved in Male Reproductive Disorders Associated With Possible Exposure to Endocrine Disrupting Agents?

Principal Investigator

Prof. Patrick Fénichel
Groupe de Recherche en Endocrinologie et Reproduction
INSERM
Faculté de Médecine
Avenue de Vaombrose, 28
F - 06107 Nice Cedex 02
Patrick.Fenichel@unice.fr

Collaborators

Dr. Georges Pointis - INSERM
georges.pointis@unice.fr

Description

The objective of the project is to verify whether impairment of expression and/or function of the gap junctional connexins (elements of the gap junction structure; this structure facilitates “communication” between cells) could be implicated in human male reproductive disorders. An in vitro model system (immortalised Sertoli cells) will be used to verify the possible link of hormonal regulation of connexins with endocrine disruptors.

Related Publications

Defamie N, Mograbi B, Roger C, Cronier L, Malassine A, Brucker-Davis F, Fenichel P, Segretain D and Pointis G. Disruption of gap junctional intercellular communication by lindane is associated with aberrant localisation of connexion43 and zonula occludens-1 in 42GPA9 Sertoli cells. Carcinogenesis : Vol. 22, Issue 9, 1537-1542, September 2001.

LRI funding: €50,000

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