Cefic-lri Programme | European Chemical Industry Council

ECO23-VUAM: Time-Integrative Passive sampling combined with Toxicity Profiling (TIPTOP): an effect-based strategy for cost-effective chemical water quality assessment

Principal Investigator

Dr. Timo Hamers
Institute for Environmental Studies (IVM)
VU University Amsterdam
De Boelelaan 1087
1081 HV Amsterdam
The Netherlands
timo.hamers@vu.nl
Tel. +31 20 598 9529 (direct)
Fax. +31 20 598 9553

Collaborators

Dr Foppe Smedes, Senior Analytical Environmental Chemist (Deltares), Utrecht,  NL, foppe.smedes@deltares.nl
Dr Dick de Zwart, Senior Ecological Risk Assessor, RIVM (National Institute for Public Health & The Environment)

Description

The TIPTOP study will test the following two hypotheses:

  • Compound-by-compound chemical water quality assessment based on concentrations of target-analyzed pollutants is toxicologically and ecologically less relevant and thereby less protective than risk assessment based on bioassay responses to the complex mixture of pollutants as a whole;
  • A combination of time-integrative passive sampling followed by toxicity profiling is a more cost-effective,  alternative to determine if “good surface water chemical status” is reached than the currently applied chemical analysis of a continuously expanding suite of individual substances.

To test these hypotheses, TIPTOP will evaluate a combined strategy of suitable passive sampling and toxicity profiling techniques for the assessment of adverse toxic effects of chemicals on ecological quality of surface waters. The following objectives have been set for this TIPTOP study:

1) Perform passive sampling at six well-characterized WFD locations in the Dutch delta and in effluents from two urban wastewater treatment plants (WWTPs) with different industrial contributions to the waste water influent;

2) Determine toxicity profiles for the sample extracts in a battery of bioassays consisting of seven mechanistic in vitro bioassays and six small-volume in vivo bioassays representing four trophic levels;

3) Collect and determine concentrations of pollutants in passive samplers and water from the sampling sites;

4) Make ecologically relevant interpretations of the available chemical concentrations analyses and the observed toxicity profiles (including benchmarking to a WWTP toxicity profile) and compare these with the observed ecological status;

5) Critically evaluate the applied strategy in line with results of similar previous approaches (published and unpublished), and indicate necessary improvements/validity tests;

6) Propose a cost-effective and technically feasible protocol for time-integrative passive sampling combined with toxicity profiling, together with a framework for assessing acceptability.

Related Publications

Publications:

Zwart N, Nio SL, Houtman CJ, De Boer J, Kool J, Hamers T, Lamoree M. High-throughput Effect-Directed Analysis using downscaled in vitro reporter gene assays to identify endocrine disruptors in surface water. Environ Sci Technol. 2018 Apr 3;52(7):4367-4377.

Hamers T, Legradi J, Zwart N, Smedes F, De Weert J, Van den Brandhof EJ, Van de Meent D, De Zwart D. Time-Integrative Passive sampling combined with Toxicity Profiling (TIPTOP): an effect-based strategy for cost-effective chemical water quality assessment. Environ Toxicol Pharmacol. 2018 Dec;64:48-59.

Presentations:

Hamers T. Time-Integrative Passive sampling combined with TOxicity Profiling (TIPTOP) to assess mixture toxicity of surface waters. ECETOC (European Centre for Ecotoxicology and Toxicology of Chemicals) Annual Environment Progress Review, February 2016, Brussels, BE.

Hamers T. Time Integrative Passive sampling combined with Toxicity Profiling (TIPTOP) – an effect based strategy for cost-effective chemical water quality assessment STOWA (Foundation for Applied Research Water Management) Monitoring Conference, April 2016, Arnhem, NL.

Hamers T, Smedes F, De Weert J, Van den Brandhof EJ, Van de Meent D, De Zwart D. Passive sampling and toxicity profiling: a case study in Rivers Meuse and Rhine, The Netherlands. 26th SETAC Europe Annual Meeting, May 2016, Nantes, FR.

Hamers T, Smedes F, De Weert J, Van den Brandhof EJ, Van de Meent D, De Zwart D. Passive sampling and toxicity profiling: a case study in Rivers Meuse and Rhine, The Netherlands. 18th CEFIC-LRI Annual Workshop, November 2016, Brussels, BE.

Hamers T, Smedes F, De Weert J, Van den Brandhof EJ, Van de Meent D, De Zwart D. TIPTOP: Time Integrative Passive sampling combined with Toxicity Profiling: an effect based strategy for cost-effective chemical water quality assessment. ILOW (Integral Laboratory Counsel Water Quality Managers) Symposium, February 2017, Utrecht, NL.

Hamers T, Smedes F, De Weert J, Van den Brandhof EJ, Van de Meent D, De Zwart D. TIPTOP: Time Integrative Passive sampling combined with Toxicity Profiling: an effect based strategy for cost-effective chemical water quality assessment. NORMAN workshop Integrated Exposure and Effects Assessment, April 2017, Utrecht, NL.

Posters:

Hamers T, Smedes F,De Zwart D. Time Integrative Passive sampling combined with Toxicity Profiling (TIPTOP): an effect based strategy for cost-effective chemical water quality assessment. 16th Cefic-LRI Annual Workshop, November 2014, Brussels, BE.

Timeline: May 2014 > April 2016

LRI funding: € 299 675

Cefic-Lri Programme Responsible Care

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