This project will support the acceptance of the Cefic MIAT Decision Tree by identifying appropriate monitoring studies of chemicals in the EU and applying the Decision Tree to the data generated by the studies. The goal of this project is to demonstrate to experts in government and academia that the Decision Tree 1) can be applied to data from a wide range of European studies, including studies with large numbers of measured compounds, and 2) provides useful insights on the risks posed by exposures to combinations of chemicals. The project will investigate the application of the Decision Tree to both human health and ecological effects.
The project poses a number of administrative challenges. Monitoring data in the EU tend to be scattered across many agencies and organizations. Gaining access to the raw data from the surveys is also a challenge since many organizations only release summaries of monitoring data. Finally, human health and ecological toxicity criteria are not readily available for many of compounds identified in monitoring surveys. To address these challenges, the project team will include experts in environmental monitoring who are familiar with the governmental agencies and academic groups who perform such surveys and individuals with experience in the standard setting process. One such survey dataset has already been identified, (Robert Loos, Bernd M. Gawlik, Giovanni Locoro, Erika Rimaviciute, Serafino Contini, Giovanni Bidoglio. 2008. EU Wide Monitoring Survey of Polar Persistent Pollutants in European River Waters. European Commission, Joint Research Centre, Institute for Environment and Sustainability Contact information) and will be included in the project.
Price et al., A decision tree for assessing effects from exposures to multiple substance. Environmental Sciences Europe 2012, 24:26
Price et al., An application of a decision tree for assessing effects from exposures to multiple substances to the assessment of human and ecological effects from combined exposures to chemicals observed in surface waters and waste water effluents. Environmental Sciences Europe 2012, 24:34