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ADME-B(ioaccumulation) Calculator

ADME-B(ioaccumulation) Calculator is a toxicokinetic analysis tool to aid in the interpretation of the results from dietary bioaccumulation tests of non-ionic hydrophobic organic chemicals in fish following protocols of the Organization for Economic Co‐operation and Development Guideline 305 (OECD 305). The ADME-B Calculator is an outcome of project ECO33 “Use and Interpretation of Dietary Bioaccumulation Tests for Hydrophobic Organic Chemicals”.

The ADME-B Calculator is a simple spreadsheet tool based on a refined 2-compartment toxicokinetic framework that describes the absorption, distribution, metabolism and excretion (ADME) of non-ionic hydrophobic organic chemicals in fish from the results of OECD 305 dietary bioaccumulation tests. The ADME-B Calculator allows the user to enter experimental data and test conditions for deriving the kinetic parameters describing the ADME processes in the test animals as well as bioaccumulation metrics, including biomagnification factors and bioconcentration factors, which can be used in a weight of evidence approach to aid bioaccumulation assessment. The ADME-B Calculator provides uncertainty estimation for bioaccumulation metrics from dietary bioaccumulation tests and can be applied to account for the effect of the exposure pathway in a field scenario by characterizing the ADME profile of chemicals in fish.


Access

ADME-B(ioaccumulation) Calculator is freely available here.

 

References

Gobas FAPC, Lee YS, Lo JC, Parkerton TF, Letinski DJ. A toxicokinetic framework and analysis tool for interpreting Organization for Economic Co‐operation and Development Guideline 305 dietary bioaccumulation tests. Environ Toxicol Chem (in press).

Lo JC, Letinski DJ, Parkerton TF, Campbell DA, Gobas FAPC. 2016. In vivo biotransformation rates of organic chemicals in fish: Relationship with bioconcentration and biomagnification factors. Environ Sci Technol 50:13299–13308.

Gobas FAPC, Lo JC. 2016. Deriving bioconcentration factors and somatic biotransformation rates from dietary bioaccumulation and depuration tests. Environ Toxicol Chem 35:2968–2976.

Lo JC, Campbell DA, Kennedy CJ, Gobas FAPC. 2015. Somatic and gastrointestinal in vivo biotransformation rates of hydrophobic chemicals in fish. Environ Toxicol Chem 34:2282–2294.

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