The MEGen (Model Equation Generator) software is a ‘proof of concept’ intuitive user interface for the rapid generation and analysis of physiologically-based pharmacokinetic (PBPK) models which was successfully developed by Cefic LRI in collaboration with HSL under project B3.7 “Rapid Generation and Analysis of Physiologically-Based Pharmacokinetic Models (PBPK Model)”.
MEGen enables a user to describe physiology, biology and toxicology in order to output a set of mathematical equations that emulate the information supplied by the user and constitute a PBPK model. During this process, the software interrogates a built-in database, supplying pertinent data for use within the model. The resulting mathematics can be translated and imported into a number of commercial modelling packages where it may be visualised and exercised.
Another feature of the MEGen model building process is the provision of a transparent and auditable trail. MEGen provides a schematic diagram of a built model along with a corresponding table listing the value, units, source, origin and reference for each parameter specified. The diagrams and tables can be exported directly into documents prepared in standard word processors.
MEGen is freely available under the General Public Licence regulation at http://xnet.hsl.gov.uk/megen/.
George Loizou, Martin Spendiff, Alex Hogg and Eric Pryde. The Rapid Generation of Physiologically Based Pharmacokinetic Models.
Martin Spendiff, George Loizou, Alex Hogg. The Rapid Generation of Physiologically Based Pharmacokinetic Models using MEGen.