Inhalation and/or dermal exposure may lead to uptake in the body. PBPK-modelling can estimate the level of a chemical in body tissues and body fluids following inhalation and/or dermal exposure. Generic PBPK-models contain algoritmes as QSPRs (=Quantitative Structure-Property Relationships) for blood:air and tissue:blood partitioning. That is why such a PBPK model can be used even when experimental partition characteristics of a compound are lacking.
IndusChemFate is a newly developed generic PBTK (Physiologically Based Toxicokinetic) model for the derivation of human biomonitoring equivalent guidance values (BEGV) for multiple (data-poor) chemicals. It is a first tier or screening tool that requires a minimum of input data. It makes it possible to estimate biological monitoring guideline values as equal to airborne limit vales. In addition, it may be of value in route to route extrapolation in regulatory toxicology.
This 1-day course is designed to introduce participants to the background of this tool. The participants will get insight in how to convert inhalation and dermal exposure to organ and tissue concentrations.
The course will cover:
Presenters include:
Who should attend?
The IndusTox IndusChemFate Workshop will take place on 22 June 2010 at Cefic offices in Brussels. Click here to download the flyer of the workshop. For more information and registrations please contact: frans.jongeneelen@industox.nl. Click here to view the poster of the IndusChemFate model.
