Cefic-lri Programme | European Chemical Industry Council

2013 ICCA-LRI and NCATS Workshop: “What Is Normal?” Implications for Chemical Safety Assessment

Start date: 11 Jun. 2013

End date: 12 Jun. 2013

The focus of this year’s workshop is the provocative question of what is normal for humans regarding responses to chemical exposures. Which exposures to chemicals or mixtures of chemicals fall within the normal range of adaptability for a cell, tissue, organ, or whole system such that adverse outcomes do not occur? This concept of an intersection between exposure and biological function that can initiate early changes but also initiate adaptive stress responses that result in a return to normal biological function was previously presented in the Toxicity Testing for the 21st Century: A Vision and a Strategy (National Research Council 2007). What is the normal range of variability among important toxicological endpoints? How might age, health status, nutrition, or pre-existing susceptibilities impact adaptability? Which recent innovations in in vitro and animal model systems can advance our evaluation of what is normal? This workshop will examine these questions from several perspectives through a combination of plenary and panel discussion sessions.


The 2013 ICCA-LRI and NCATS workshop will be held in Santa Fe, NM in collaboration with the U.S. National Institutes of Health’s National Center for Advancing Translational Sciences (NCATS). A draft programme is already available.


For more information about registration and logistics, please visit www.americanchemistry.org.


Click here to download the flyer of the workshop.

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