Cefic-lri Programme | European Chemical Industry Council

2nd IndusChemFate Workshop

Start date: 11 Nov. 2010

Inhalation and/or dermal exposure may lead to uptake in the body. PBPK-modelling can estimate the level of a chemical in body tissues and body fluids following inhalation and/or dermal exposure. Generic PBPK-models contain algoritmes as QSPRs (=Quantitative Structure-Property Relationships) for blood:air and tissue:blood partitioning. That is why such a PBPK model can be used even when experimental partition characteristics of a compound are lacking.

IndusChemFate is a newly developed generic PBTK (Physiologically Based Toxicokinetic) model for multiple (data-poor) chemicals. It is a first tier or screening tool that requires a minimum of input data. It allows to estimate concentrations in body fluids equal to airborne limit values. In addition, route to route extrapolation can be modelled. The software is available as a freeware application in Microsoft Excel. Click here to download the software application and the user manual.

The workshop will cover:

  • Explanation of the generic PBPK tool: IndusChemFate
  • Demonstration of calculation and visualisation of body tissues and fluid concentrations after inhalation, dermal exposure and/or oral intake with the software application in MS-Excel.
  • Training in real life application of IndsuChemFate for workers exposures


The programme of the workshop is finalised and already available.


Dr. Wil ten Berge : , a toxicologist with over 30 years experience in modelling and toxicology
Dr. Frans Jongeneelen : , an occupational hygienist/toxicologist with 25 years of experience in human biomonitoring and chemical risk assessment.

Target group:

– Industrial professionals responsible for conducting or evaluating risk assessments on consumer and occupational exposure to chemicals.
– Occupational health professionals.
– Toxicologists interested in physiologically based pharmacokinetic modelling

Workshop fee:

A fee of €150 (excl. VAT/BTW) is needed to cover direct costs. The fee includes: administration costs, lunch, drinks and workshop handouts.

Registration is now open!

Complete the registration form and send it by e-mail to . You will receive a confirmation and an invoice. Only 30 participants will be accepted.

Click here to view the workshop flyer or visit the website of IndusTox Consult for more information.

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