Principal Investigator
Dr Jon Arnot
ARC Arnot Research & Consulting Inc.
36 Sproat Avenue
Toronto, ON
M4M 1W4
Canada
jon@arnotresearch.com
Collaborators
Dr. James Armitage, AES Armitage Environmental Sciences, Inc., Toronto, ON, CA, james.armitage@utoronto.ca
Liisa Toose, MSc, ARC Arnot Research & Consulting Inc., Toronto, ON, CA, liisa@arnotresearch.com
Dr. Karen Foster, Foster Environmental Research, Peterborough, ON, CA, karen@fosterenvironmental.ca
Lauren Hughes, MSc, ARC Arnot Research & Consulting Inc., Toronto, ON, CA, lauren@arnotresearch.com
Dr. Michelle Embry, Health and Environmental Science Institute, Washington, DC, USA, membry@hesiglobal.org
Description
The general objective of this proposal is to develop a user-friendly organizational framework and computational tool for integrating various lines of evidence in a quantitative weight of evidence (QWOE) approach to aid regulatory decision-making for bioaccumulation assessment. To satisfy this general objective:
- A tool that brings together measured data (e.g., chemical properties, in vivo and in vitro bioaccumulation and toxicokinetics) and modelled data (e.g., chemical properties, in vivo and in vitro bioaccumulation and toxicokinetics data) in a quantitative framework for a suite of bioaccumulation assessment endpoints will be developed.
- The development of the tool will consider suggestions and recommendations from stakeholders (industry, academic and regulatory scientists) throughout the project.
- The proposed “Bioaccumulation Assessment Tool (BAT Ver.1.0)” will be publicly and freely available and it will be accompanied by supporting documentation (e.g., tool description and user’s guide).
- The tool will provide the capacity for transparency and consistency in bioaccumulation assessment.
- When necessary, the organizational framework will also provide pragmatic and strategic guidance for integrated (tiered) testing strategies (i.e., possible generation of additional lines of evidence) to address uncertainty and foster confidence in the decision-making process.
Within the scope of the project, the tool will bring together the state of the science for bioaccumulation assessment. Once established The BAT Ver.1.0 will continue to evolve with the emerging science (i.e., improved mechanistic understanding of bioaccumulation processes and new data streams) and from practical experience in its application and evaluation.
Related Publications
Presentations:
Toose L, Armitage JM, Foster KL, Embry M, Arnot JA. The Bioaccumulation Assessment Tool: Overview and Case Study Application. SETAC North America 38th Annual Meeting, November 2017, Minneapolis, Minnesota, USA.
Arnot JA. The Bioaccumulation Assessment Tool (BAT). Presentation (web-based) for the European Chemicals Agency (ECHA): PBT Expert Group, September 2018, Helsinki, Finland.
Posters:
Arnot JA, Armitage JM. The Bioaccumulation Assessment Tool: An Organizational Framework for Bioaccumulation Assessment. SETAC Europe 26th Annual Meeting, May 2016, Nantes, France.
Arnot JA, Armitage JM, Foster KL, Toose L. The Bioaccumulation Assessment Tool: An Organizational Framework for Bioaccumulation Assessment. 7th SETAC World Congress/SETAC North America 37th Annual Meeting, November 2016, Orlando, Florida, USA.
Arnot JA, Armitage JM, Foster KL, Toose L, Embry M. The Bioaccumulation Assessment Tool: An Organizational Framework for Bioaccumulation Assessment. SETAC Europe 27th Annual Meeting, May 2017, Brussels, Belgium.
Toose L, Armitage JM, Foster KL, Embry M, Arnot JA. The Bioaccumulation Assessment Tool (BAT): A quantitative weight of evidence approach for bioaccumulation assessment. SETAC Europe 28th Annual Meeting, May 2018, Rome, Italy.
Toose L, Armitage JM, Hughes L, Foster KL, Embry M, Arnot JA. The Bioaccumulation Assessment Tool (BAT): A quantitative weight of evidence approach for bioaccumulation assessment. SETAC North America 39th Meeting, November 2018, Sacramento, California, USA.
