Volatile organic compounds (VOCs) are ubiquitous in indoor air and their origin is a plethora of various emission sources including building related materials, furniture, equipment and consumer and household related products. Currently, there is international recognition of the contribution of […]
Environmental exposures during fetal and early life may contribute to complex disease later in life such as allergic diseases (AD), neurodegenerative diseases and cancer. The underlying mechanisms are still undiscovered, but changes in the epigenetic regulation of gene expression (such […]
The overall aim of the proposed project is to provide a systematic and quantifiable comparison of NOAELs derived from animal studies with those from human studies for a range of chemicals and to develop robust evidence synthesis (meta-analytical) methodology combining […]
The analysis of epigenetic modifications at the level of the genome is a very promising field of research. The major question to be addressed is how the epigenome distinguishes cell types and how epigenetic variability between individuals reflects the influence […]
Masculinisation depends on adequate production of testosterone by the fetal testis within a specific'male programming window'. Disorders resulting from subtle deficiencies in this process are common in humans and environmental exposures/lifestyle could contribute causally as common therapeutic and environmental compounds […]
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