The aim of this project is to characterize adult rat testicular toxicity induced by compounds that have either an estrogenic or a non-estrogenic mode of action. To fully realise this goal, the differentiation between normal background variability (ie no effect), […]
Discussions over possible declines in male sperm counts are hampered by the lack of human data. Data is readily available, however, on sperm counts from other mammals, and this can provide helpful insight to questions regarding male fertility rates. This […]
Hypospadias is a male birth defect in which the urethral orifice is abnormally located on the ventral side of the penis. In western countries, the prevalence of hypospadias varies from 2 to 8 cases per 1000 live births. An increase […]
The research institutes will study 6000 men attending any of the 10 fertility clinics in the UK over a period of 2 years. They will be classified as either fertile or infertile on the basis of sperm parameters. Standardised methods […]
This is a study of 10,000 men, their (pregnant) partners and their new-born children. Information will be collected on the incidence of urogenital disorders such as Cryptorchidism, Hypospadia, lifestyle, working conditions of the male partner and time to pregnancy. The […]
The study will investigate sex steroid-regulated gene expression in two sexually dimorphic brain regions i.e. the preoptic region, the bed nucleus of stria terminalis and the ventromedial hypothalamic nucleus, which are part of the neural network controlling sexually dimorphic behaviours […]
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