Cefic-lri Programme | European Chemical Industry Council

Projects

ECO22-IRAS: Advancing the use of passive sampling in risk assessment and management of contaminated sediments: an inter-laboratory comparison study on measurements of freely dissolved (bioavailable) concentrations using different passive sampling formats

The main objective of this study is to map the state of the art in passive sampling sediments and to investigate which measures we can take to reduce any inter-method and -laboratory variation, in order to increase confidence in the […]

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EEM9.3-IC: Linking LRI AMBIT Chemoinformatic system with the IUCLID Substance database to Support Read-across of Substance endpoint data and Category formation

A major hurdle in using chemoinformatic systems is the lack of easily accessible data on substance identity including structures and composition e.g. constituents, impurities and additives as well as high quality, detailed endpoint data of chemical substances. This project is […]

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ECO23-VUAM: Time-Integrative Passive sampling combined with Toxicity Profiling (TIPTOP): an effect-based strategy for cost-effective chemical water quality assessment

The TIPTOP study will test the following two hypotheses: Compound-by-compound chemical water quality assessment based on concentrations of target-analyzed pollutants is toxicologically and ecologically less relevant and thereby less protective than risk assessment based on bioassay responses to the complex […]

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EMSG34.4-SYNG: Evaluation of the weanling and testosterone-stimulateed weanling rat as an alternative to the Hershberger castrated rat in the detection of coded androgens and antiandrogens

Growing concerns regarding the possibility that environmental contaminants could mimic estrogens and androgens and hence disrupt endocrine systems have led to the evaluation of test systems to detect such contaminants. One system, the weanling rat assay, has been suggested as […]

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EMSG34.4-BACR: Continuation of the Hershberger validation with the intact weanling male rat to prove equivalence to the classic castrated male rat version

The current method of assessing the (anti-)androgenic potential of a compound in vivo is through the use of the Hershberger assay.  This involves first castrating adult male rats, allowing the sexual accessory tissues to regress and then exposing the rats […]

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EMSG37-BAYER: Participation of Bayer CropScience in Phase 1A and 1B of the OECD validation work on the “Non-Spawning Fish Screening Assay” for the detection of endocrine active substances according to the OECD test protocol (ENV/JM/TG/EDTA(2002)5)

In a 21-day-assay (phase 1 B), sexually mature female and male fathead minnows (Pimephales promelas) were exposed to a weak estrogen agonist, or a weak aromatase inhibitor, under flow-through conditions. Three different test-compound concentrations, a water-only control, and a corresponding positive control […]

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ECO13: Development, application and evaluation of model-based screening procedures for PBT chemicals and POPs (SCREEN-POP)

The scientific objectives of this project are: 1.To create a tiered screening system for identifying potential PBTs and POPs amongst existing chemicals; 2.To verify whether the potential PBTs / POPs identified in the screening program are present in the European background […]

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EMSG44: Impact of physiological, lifestyle and environmental factors on the development of puberty

Puberty is the transitional period from childhood to adulthood. At puberty onset, a change in the set point (sensitivity) of the so-called ”gonadostat”, which is located in the hypothalamus, occurs. During childhood, small amounts of sex hormones produced in steroid […]

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B6-DOW: Improved hazard assessment of chemical sensitizers through testing of novel markers

The specific objectives of this project are as follows: - to provide genome-wide maps of kinetic changes in gene expression induced in draining lymph nodes following exposure of mice to a panel of selected chemicals (comprising chemicals known to cause […]

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