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Projects

B14-RIFM: Skin Sensitisation – Chemical Applicability Domain of the Local Lymph Node Assay (LLNA)

Since the publication of the OECD AOP for skin sensitisation in 2012, there have been even greater efforts to anchor the development and evaluation of new in vitro and in chemico assays to key events within the AOP. Much of […]

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ECO11 – UNEW: Towards rationally designed hazard, risk and persistency assessment: Putting the “bio” back into biodegradability tests

ECO11: Towards rationally designed hazard, risk and persistency assessment: Putting the “bio” back into biodegradability tests The objectives of this project are as follows: Objective 1a.  Determine the extent and variation in microbial diversity of environmental sources used in biodegradation […]

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ECO14-USTO: Development and validation of an abbreviated in vivo fish bioconcentration test

The overall objective of the research project is to reduce the cost and the number of animals needed to measure the bioconcentration factor (BCF) of organic chemicals in fish, using the accepted ”gold standard” OECD 305 as the point of reference. […]

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ECO12: Validation Chemicals for Assessing Biodegradation Tests

This project aims to develop a list of reference chemicals covering a range of environmental persistence and non-persistence. This reference set would be available for use to validate modifications to existing biodegradation test methods and to develop new test methods. […]

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ECO15/14-15.2-USTO: Rapid estimation of TMF using laboratory, field and computer modelling methods in aquatic organisms

Chemical bioaccumulation is an interesting scientific phenomenon and an important regulatory consideration. The production and use of chemicals that are assessed as having a high potential to accumulate can be restricted in many jurisdictions.  At the same time, recent scientific […]

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ECO16 – IRAS: Generate a validated CBR database and validate a CBR chronic toxicity range for narcotics

The general objective of the research project is to generate greater confidence and acceptance for the application of CBBs in the scientific community and in regulatory contexts. A key element of this research will be to compare model predictions that provide mechanistic […]

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