Cefic-lri Programme | European Chemical Industry Council

Complex environments

B18: Carcinogen Dose-Response Database for Threshold of Toxicological Concern (CDRD-TTC)

This project aims to generate a fully-curated, quality-controlled and publically-available database on genotoxic and non-genotoxic carcinogens. The novel database will form the basis of analysis of TTC distributions for cancer thresholds. The specific objectives of the research, in the context […]

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B17: SHINE: Target and non-target Screening of cHemicals in the Indoor enviroNment for human Exposure assessment

The last couple of years have seen substantial efforts expended on the development of sophisticated, high tier modelling of integrated exposure (including via indoor air), such as INTEGRA (developed in a CEFIC LRI project) and Merlin Expo; however these models […]

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ECO28: Modelling approaches for a scenario based assessment of chemically induced impacts on aquatic macroinvertebrate communities (MACROMOD)

The ecological risk assessment (ERA) of chemicals aims at quantifying the likelihood of adverse ecological effects posed on populations and the communities they comprise (sensu Forbes et al. 2011). Effects caused by the exposure of organisms to toxicants can however […]

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N5-FRAU: Histopathology of rats exposed to Barium sulfate nanoparticles by life-time inhalation exposure – Effects and Biokinetics

A lot of data are known regarding acute and subacute toxicity of nanomaterials, whereas the long term outcome of inhalation exposure to nanomaterials is still unclear. Long-term inhalation exposure data are only available for nano-TiO2 and Carbon black particles at […]

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ECO30-ARC: Expanding the applicability domain of the chemical activity approach for hazard and risk assessment

The general objectives of this proposed research are (a) to link the toxicity of chemicals to their chemical activity, (b) to expand and critically evaluate the applicability domain of chemical activity for interpreting toxicity data, and (c) to facilitate the […]

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ECO29-UVA: Application of chemostat systems to include adaptation of microbial communities in persistency testing (CHEMADAPT)

Persistence in the environment is a key property in assessing the environmental risks of organic chemicals. Currently, persistence is most often determined using screening tests such as the OECD ready biodegradability tests and sometimes with simulation tests designed to model […]

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ECO27-USHE: Chemicals: Assessment of Risks to Ecosystem Services (CARES)

Aim: To facilitate engagement of the chemical industry, academia and regulators to help develop and evaluate the ecosystem service approach in guiding risk assessment schemes for any type of xenobiotic chemical. Objectives: Review and evaluate state of knowledge and available […]

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ECO8.3-NC3Rs-EAWAG: Round-robin test of the RTgill-W1 cell line assay to study its robustness in establishment and inter-laboratory comparability

To accomplish international recognition of the RTgill-W1 cell line assay for predicting acute toxicity to fish, the project aims to initiate a round-robin trial in order to test the robustness of the established methodology. In particular, the team aims to evaluate the […]

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ECO27-USHE: Chemicals: Assessment of Risks to Ecosystem Services (CARES)

Aim: To facilitate engagement of the chemical industry, academia and regulators to help develop and evaluate the ecosystem service approach in guiding risk assessment schemes for any type of xenobiotic chemical. Objectives: 1. Review and evaluate state of knowledge and […]

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LRI AWARD 2010: In Quest of new fingerprints of exposure to VOC from consumer products

Volatile organic compounds (VOCs) are ubiquitous in indoor air and their origin is a plethora of various emission sources including building related materials, furniture, equipment and consumer and household related products. Currently, there is international recognition of the contribution of […]

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