Cefic-lri Programme | European Chemical Industry Council

Complex environments

ECO44 – A toxicokinetic mammalian modelling framework for B assessment

The general objective of this project is to build a toxicokinetic (TK) modelling framework for mammals and develop and integrate various data streams for mammalian B assessment. This research will expand the development, evaluation, and application of the CEFIC-LRI funded […]

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ECO42: Fate-directed toxicity testing and risk assessment of UVCBs

The objectives of this project are (1) to develop and test new approaches for fate-directed ecotoxicity assessment of UVCBs based on new combinations of analytical methods, dosing methods, fate directed fractionation, toxicity testing and models, (2) to conduct a case […]

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ECO45: Chemicals – Assessment of Risks to Ecosystem Services (CARES) II

This project aims to evaluate the practical applicability of an ecosystem services approach to prospective and retrospective chemical risk assessment.

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B18: Carcinogen Dose-Response Database for Threshold of Toxicological Concern (CDRD-TTC)

This project aims to generate a fully-curated, quality-controlled and publically-available database on genotoxic and non-genotoxic carcinogens. The novel database will form the basis of analysis of TTC distributions for cancer thresholds. The specific objectives of the research, in the context […]

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B17: SHINE: Target and non-target Screening of cHemicals in the Indoor enviroNment for human Exposure assessment

The last couple of years have seen substantial efforts expended on the development of sophisticated, high tier modelling of integrated exposure (including via indoor air), such as INTEGRA (developed in a CEFIC LRI project) and Merlin Expo; however these models […]

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ECO28: Modelling approaches for a scenario based assessment of chemically induced impacts on aquatic macroinvertebrate communities (MACROMOD)

The ecological risk assessment (ERA) of chemicals aims at quantifying the likelihood of adverse ecological effects posed on populations and the communities they comprise (sensu Forbes et al. 2011). Effects caused by the exposure of organisms to toxicants can however […]

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N5-FRAU: Histopathology of rats exposed to Barium sulfate nanoparticles by life-time inhalation exposure – Effects and Biokinetics

A lot of data are known regarding acute and subacute toxicity of nanomaterials, whereas the long term outcome of inhalation exposure to nanomaterials is still unclear. Long-term inhalation exposure data are only available for nano-TiO2 and Carbon black particles at […]

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ECO30-ARC: Expanding the applicability domain of the chemical activity approach for hazard and risk assessment

The general objectives of this proposed research are (a) to link the toxicity of chemicals to their chemical activity, (b) to expand and critically evaluate the applicability domain of chemical activity for interpreting toxicity data, and (c) to facilitate the […]

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ECO29-UVA: Application of chemostat systems to include adaptation of microbial communities in persistency testing (CHEMADAPT)

Persistence in the environment is a key property in assessing the environmental risks of organic chemicals. Currently, persistence is most often determined using screening tests such as the OECD ready biodegradability tests and sometimes with simulation tests designed to model […]

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ECO27-USHE: Chemicals: Assessment of Risks to Ecosystem Services (CARES)

Aim: To facilitate engagement of the chemical industry, academia and regulators to help develop and evaluate the ecosystem service approach in guiding risk assessment schemes for any type of xenobiotic chemical. Objectives: Review and evaluate state of knowledge and available […]

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