Projects

Human Health

B15.3 – ECEL v3.0: Technical improvements and population of the integrated risk management measure (RMM) library

B15.3 is an extension of the “Cefic-LRI B15-2 project: Development of an integrated risk management measure library”. The main goal of this proposal is to upgrade ECEL v2.0 to ECEL v3.0 such that it is a well-designed, user-friendly tool with […]

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Intelligent testing

B18.2 – Incorporation of repeated dose study information for non-DNA-reactive carcinogens into the CPDB database and analysis of threshold values

This project is planned as extension of the project CEFIC LRI project B18, named “Database on Carcinogen Dose-response, including Information on DNA-reactivity, for TTC and beyond”, which is currently in its reporting phase. In this previous project, we updated the […]

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Human Health

B12.3 – Assessing the relevance of the dust contribution in consumer exposure to substances from consumer products and articles (DustEx extension)

Human exposure to semi-volatile organic compounds (SVOCs) present in materials is of great interest because of the large number of SVOCs used for different purposes in different materials; ranging from plasticizers in PVC to flame retardants in upholstery and clothing […]

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Intelligent testing

AIMT5.2 – A computational model for neural tube closure for in silico predictive toxicology of neural tube defects

The objective of this project is to translate the developmental ontology for neural tube closure, which was constructed in the LRI AIMT-5 project, into a computational model for predictive toxicology of neural tube defects. This represents a penultimate step for […]

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Human Health

B21 – In Vitro Data to Parameterise PBPK Models For Inhalation Exposure

This project aims at the generation and application of physiologically derived transport parameters in a PBPK model focusing on a more detailed description of substance uptake through the respiratory tract/via the inhalational route. This PBPK model is aimed to be […]

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Complex environments

ECO47 – SNAPFISH: Searching for refiNed in vitro Approaches to Predict bioconcentration in FISH

Chemical regulations require information as to whether a chemical is bioaccumulative. Steady-state bioconcentration factors (BCFs) in fish reflect the net result of the various chemical uptake versus loss processes and can be determined directly.

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Human Health

C7 – ELUMICA – Elucidating Microbial Metabolic Capacity

This project will carry out collaborative, mechanistically oriented research centered around the following three aims: Identify and quantify alterations in endogenous and xenobiotic-derived microbial metabolites; provide a basis to examine interspecies and interindividual differences in intestinal microbial metabolism; and develop […]

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Human Health

EMSG59 – Developing a quantitative AOP for liver-mediated thyroid modulation after prenatal exposure to a xenobiotic compound in the rat

This project aims at understanding the consequences of chemical-induced changes in liver physiology on thyroid hormone balance and related adverse health effects. The project will focus on prenatal exposure and development of the foetus and new-born in the rat as […]

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Complex environments

ECO50 – Incorporating spatial and seasonal variability in community sensitivity into chemical risk assessment (GETREAL)

GETREAL will provide this information on the variability in chemical sensitivity and explore its consequences for risk assessment.

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Complex environments

ECO49 – Microplastic Effect Thresholds for Aquatic Species (METAS)

Microplastics research has grown substantially over the past years due to concerns with the public, the scientific community and environmentalist groups. They are often detected in environmental compartments but the hazards and risks they pose are debated and largely unknown.

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