Cefic-lri Programme | European Chemical Industry Council

Cefic-LRI updates online toolbox for chemical risk assessment

Cefic’s Long Range Research Initiative (LRI) has updated some of its quality-assured databases and key prediction tools for risk assessment and toxicity testing of chemicals.

Freely available and mainly intended for European and national regulatory agencies, industry and academia, the main purpose of these tools is to help users in the preparation of regulatory dossiers such as REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) and GHS (Globally Harmonized System of Classification and Labelling of Chemicals), as well as for research and development initiatives.

This spring, 4 novel tools have been added to the toolbox, covering topics such as bioaccumulation (ADME-B), toxicokinetic modelling (R-Vis), organism survival modelling (GUTS) and thresholds of toxicological concern (TTC):

ADME-B(ioaccumulation) Calculator is a toxicokinetic analysis tool to aid in the interpretation of the results from dietary bioaccumulation tests of non-ionic hydrophobic organic chemicals in fish.

TTC-NGC (Threshold of Toxicological Concern dataset for non-genotoxic carcinogens) is a dataset developed to identify most sensitive endpoints and/or point of departures after chronic oral exposure for non-genotoxic carcinogens.

GUTS The General Unified Threshold Model of Survival is a user-friendly, freely-available and open-source software for standard General Unified Threshold model of Survival (GUTS) applications.

R-VIS – is an open Access PBPK Modelling Platform providing an intuitive, freely available modelling tool for biologically based, quantitative safety and risk assessment of chemicals. An important feature is the prediction of human in vivo doses from alternative-to-animal systems.

More information about these tools and others are available at cefic-lri.org/lri-toolbox

To have an overview of all the LRI tools, click here.

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