Cefic-lri Programme | European Chemical Industry Council

Intelligent testing

ECO 55: Assessing the Impact of Sample Collection on Microbial Population and Validity Criteria in the OECD 309 Surface Water Mineralisation Test

This project will provide improved guidance on surface water sample collection, storage and treatment including a scientifically defensible maximum range between water source sampling and experimental temperature and a suite of quantitative and qualitative tests that further demonstrate inoculum viability […]

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ECO51 – SWiFT: Strengthening weight of evidence for FET data to replace acute fish toxicity

The use of fish embryo toxicity (FET) data for hazard assessments of chemicals, in place of acute fish toxicity (AFT) data, has long been the goal for many environmental scientists.

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B22 – TMEx-Complex: Tiered Methods for Quantifying Exposure to Complex Substances

Human exposure to chemicals is usually studied and understood in terms of the effect of a single pure chemical, but most humans are exposed to mixtures of chemicals. The project is focussed on determining how human exposure to chemicals is […]

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B18.2 – Incorporation of repeated dose study information for non-DNA-reactive carcinogens into the CPDB database and analysis of threshold values

This project is planned as extension of the project CEFIC LRI project B18, named “Database on Carcinogen Dose-response, including Information on DNA-reactivity, for TTC and beyond”, which is currently in its reporting phase. In this previous project, we updated the […]

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AIMT5.2 – A computational model for neural tube closure for in silico predictive toxicology of neural tube defects

The objective of this project is to translate the developmental ontology for neural tube closure, which was constructed in the LRI AIMT-5 project, into a computational model for predictive toxicology of neural tube defects. This represents a penultimate step for […]

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ECO43: Improving sediment toxicity testing design and data interpretation for very hydrophobic substances

The general objective of the proposed research is to improve sediment toxicity testing design, performance, and data interpretation for VHOCs and to develop guidance in order to maximize realism and value of future testing and thereby to support product and […]

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ECO41: Enhanced Screening Methods to Determine Bioaccumulation Potential of Chemicals in Air-Breathing Species

This project plans to develop an approach for assessing bioaccumulation of neutral hydrophobic organic chemicals in air-breathing species based on physical chemical properties (i.e. KOW and KOA) and in-vitro biotransformation bioassay data using mammalian liver S9 in vitro bioassays.

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ECO35: Interference of hepatotoxicity with endocrine activity in fish

The project proposed is driven by the hypothesis that hepatotoxicity may positively or negatively interfere with vitellogenin production, which is used as a key marker of endocrine activity in current OECD test guidelines 229, 230 and 234 and the proposed […]

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ECO34: A tiered testing strategy for rapid estimation of bioaccumulation by a combined modelling – in vitro testing approach

The overall objective of our research is to reduce the uncertainty related to the estimation of bioaccumulation of organic chemicals in fish in ecological risk assessment (ERA). Based on a combination of different in vitro approaches to estimate chemical uptake […]

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ECO32: Environmental risk assessment of poorly soluble substances: Improved tools for assessing biodegradation, (de)sorption, and modeling

This project proposal will answer the following questions: Objective: How can the aqueous phase biodegradation kinetics of poorly water soluble substances be measured without the influence of bioavailability factors, i.e., without (de)sorption effects? Objective: How can the desorption rates of […]

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