Intelligent testing
EEM9-PGEU: Quantitative Structure-Activity Relationships software for data management
The software system will consist of functional modules allowing evaluation of the data stored in a database and various user interface modules. Compounds database will contain chemical structure, identifiers (including CAS numbers), imported descriptors and experimental data. The functional modules […]
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A2.3: International Workshop on Methods to Determine Dermal Permeation for Human Risk Assessment
This Workshop was designed to bring together relevant expertise and to reach a consensus recommendation on a standardised protocol for in vitro determination of permeability coefficients. The proposed protocol is intended, in the first instance, for testing aqueous soluble chemicals […]
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ECO1B-WRCN: Comparison of Marine and Freshwater Data and Test Methods Review of Literature – Phase I
The environmental risk posed by any new chemical produced or used in substantial quantities in the EU had to be assessed. This process involved estimating the concentration of the substance that could be present in water without harming aquatic life. […]
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R2-BIHH: The Physiological and Bronchial Inflammatory Marker Response to Exposure in the Workplace in Patients With Occupational Asthma
Occupational asthma is the commonest occupational lung disease, accounting for 5% of all cases of asthma, and incidence is rising. Sufferers lose on average half their total take-home income (including compensation) for four years after diagnosis. Whilst the clinical and […]
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ECO1C-TUD: Comparison of Soil and Sediment Ecotoxicity Data and Test Methods
Existing data on ecotoxicity of chemicals for water, sediment and soil varies widely in quality, quantity, validity, and how representative it is. This is due to environmental concerns having initially focused water, with soil and sediment taken into account only […]
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B1.1-FRAU: Identification of Structure Activity Relationships Alerts for Substances With Low NOELs (REPDOSE)
The toxicological data profiles of many of the more than 100,000 substances included in the EINECS are incomplete. Scientific tools are needed to minimize test requirements and to prioritise research needs. Here consideration of Structure Activity Relationships (SAR) could be […]
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ECO2A-ASTRA: Understanding and Measurement of Persistence in the Marine and Terrestrial Compartments
The persistence of a chemical in the environment - how resistant it is to being broken down in nature - is hard to predict. Its tendency to build up in living organisms - to bioconcentrate or bioaccumulate - is similarly […]
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B2.1-TNO: Characterisation of Uncertainty and Variation in Assessment of Chronic Occupational Exposure
Many adverse health effects of chemical exposure occur after repeated contact over long periods. In assessing the risks of such chronic effects in the workplace, "reasonable worst case" estimates of exposure during a shift or working day are often used. […]
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MISTRA: A New Strategy for the Risk Management of Chemicals: MISTRA and Persistence
To evaluate the persistency of the selected model compounds in the environmental matrices air, water, soil and sediment. Reaction mechanisms and degradation pathways of the model compounds are studied. A theoretical approach will be made to arrive at the conceptual […]
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