The general objectives of this proposed research are (a) to link the toxicity of chemicals to their chemical activity, (b) to expand and critically evaluate the applicability domain of chemical activity for interpreting toxicity data, and (c) to facilitate the […]
REACH Guidance for Chemical Safety Assessment makes use of mathematical simulation of the retention of chemical substances during waste water treatment. REACH R-16 describes the use of the model SimpleTreat, developed by Struijs and co-workers at RIVM, which simulates the […]
In order to fully test the NER for its potential ecotoxicity, an evaluation of extracted residues will also be performed. Currently there are no standard methods, except for isolation and testing of each transformation product. An approach that tests the […]
The main objective of this project is to use a mechanistic framework to develop and propose a high-throughput tiered-testing strategy for screening and prioritizing chemicals for FELS testing (OECD 210). The main objective can be divided into four parts: Establish […]
The general objective of this proposed research is to improve the mechanistic understanding of bioaccumulation of ionogenic organic chemicals (IOCs) in aquatic organisms, primarily fish, in the form of mass balance models and to increase the confidence of applying these […]
In this project, we intend to investigate two hypotheses that should (i) help better understand the value and information content of the existing OECD 308 protocol, and (ii) help develop an improved test strategy for assessing persistence in sediment and […]
The overall goal of this project is to characterize the potential in vitro and in vivo activities of plant-derived endocrine active compounds (EACs) versus synthetic substances and to evaluate potential combinatory effects of relevance to fish reproductive health. In particular, the […]
The primary aim of this project is to develop improved methods for assessing potential effects of contaminated sediments on aquatic microorganisms, plants and invertebrates within and across different taxonomic groups, to be applied in a regulatory context such as REACH. The objectives […]
This project aimed to create an integrated software package to assess the transport of chemical pollutants in the environment. It provided European and national regulatory agencies and industry with a state-of-the-art tool for better prediction of concentrations of chemicals - […]
Existing data on ecotoxicity of chemicals for water, sediment and soil varies widely in quality, quantity, validity, and how representative it is. This is due to environmental concerns having initially focused water, with soil and sediment taken into account only […]
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