Intelligent testing
ECO7: Development of a Reference Database (Bioconcentration Factors, BCF)
B3.3: The Intake Fraction (iF) concept: modelling, expansion and application tests
In order to help correlate the exposure of a population to a toxicant directly to the source of exposure, researchers have developed a concept called the intake fraction (iF), which is a dimensionless variable. The estimation of the iF relationship […]
EMSG30B2: Evaluation of Fish Reproduction Test
EMSG30B1: Evaluation of Fish Development Test
EMSG42: Increase of the robustness of the fish endocrine assay and avoidance of irrelevant endpoints
The objective of this study was to determine the influence of the test items potassium permanganate, 2-methoxyethanol and octanol to reproduction and the endocrine system of fathead minnow (Pimephales promelas). For this purpose, mature male and female fathead minnow were exposed in […]
21DAY: Phase 3 of the validation of the OECD Fish Screening Assay
The eight studies in the attached report were conducted as part of OECD Test Guideline program to validate a standardized OECD protocol for a 21-day fish screening assay for the detection of endocrine active substances (i.e. estrogen, aromatase inhibitors, androgen). […]
D2.2-VITO: Generation and Application of a Model to Determine Intra- and Inter-individual Variation in Biomarkers
Biomarkers which reflect levels of pollutants in the human body offer a unique opportunity to investigate impact of environmental pollution on humans. Biomarker levels in the general population are influenced by genetic, physiological and external factors. Knowledge on which factors […]
EEM1-ASTRA: Identification and Evaluation of Emission Databases in Europe
Estimating how much of a particular chemical is released to the environment is key to assessing likely levels of exposure and risk to humans and the environment. Such estimates are often based on very general information due to a lack […]
CC2-MRCT: Gene Expression Profiling of Skin Carcinogenesis in Mice Using cDNA Microarrays
Skin cancers are very common in humans - with around one million cases/year in the US - and their development can be affected by stimulators of growth such as certain chemicals. Although initiation is clearly extremely important, clonal expansion (promotion) […]
