Intelligent testing

Intelligent testing Human Biomonitoring

HBM4-VITO:Understanding inter- and intra-individual variability in HBM spot samples

In many large-scale human biomonitoring (HBM) surveys, single samples of blood, urine or other bodily matrices are collected from large numbers of individuals recruited from the general population. These HBM surveys aim to obtain information on the distribution of exposures […]

Intelligent testing Environment

ECO17-WAG: Evaluation of test methods for measuring toxicity to sediment organisms

The primary aim of this project is to develop improved methods for assessing potential effects of contaminated sediments on aquatic microorganisms, plants and invertebrates within and across different taxonomic groups, to be applied in a regulatory context such as REACH. The objectives […]

Intelligent testing Consumer Exposure

B8-FRAU: Threshold of Toxicological Concern (TTC) for inhalation exposure: Improvement of the TTC concept for inhalation exposure and derivation of thresholds with the database RepDose

Recent results of the analysis of Cramer classes for inhalation studies indicate that local effects of the respiratory tract and eyes dominate the very low NOEC values in Cramer class 1 and also to some extent in class 3 and […]

Intelligent testing Consumer Exposure

B7-ETHZ: Estimation of realistic consumer exposure to substances from multiple sources and approaches to validation of exposure models

This project will provide a short overview on existing methods for estimating aggregate consumer exposure, i.e. exposure that adds up from consuming different household consumer products, and is built upon the work that is already funded by LRI in response to […]

Intelligent testing Bioaccumulation and Toxicity, Persistence

ECO3A.3-USTO: Evaluation of the predictability and reversibility of environmental accumulation for substances for POP/PBT-like properties

The objectives of these project are: - to gain a quantitative understanding of how chemical and environmental characteristics interact to control long-term time trends of POP/PBT-like substances in various environmental compartments. - to test the ability of current dynamic multimedia models to […]

Intelligent testing Alternative methods and eco-relevance

ECO6.2-ILSIHESI: Pre-validation of an in vitro fish liver S9 assay to optimize the prediction of bioaccumulation

The specific objectives of this project are to support incorporation of in vitro metabolism data into BCF prediction models and to extrapolate in vitro test results to whole body biotransformation rates (kmet) to be used to refine BCF model predictions. […]

Intelligent testing Alternative methods and eco-relevance

ECO6.2-CSL: Establishing relationships of biotransformation across organisms

The overall aim of this study is to develop quantitative structure-activity relationships relating to biodegradation, biotransformation and bioaccumulation in organisms from different taxa and trophic levels and to develop relationships between biotransformation in microbial systems, invertebrates and vertebrate species. This […]

Intelligent testing Consumer Exposure

ART-TNO: Phase 1: mechanistic model and Bayesian update

Under REACH, the new chemicals policy in Europe, exposure scenarios form an essential basis for chemical risk assessment reports to show that chemicals can be used safely. This requires a tiered exposure assessment approach in which the first Tier is […]

Intelligent testing Consumer Exposure

ART.2-TNO: Advanced REACH Tool – Exposure Database development and population for version 1.5

Intelligent testing Bioaccumulation and Toxicity, Persistence

ECO9-VUA: Relationships between BCF, BMF and BAF: Improving forecasting of residues in biota in the environment based on laboratory testing

Objectives Overview Identify the key properties and parameters impacting bioconcentration factor (BCF) measurements in the laboratory and those impacting field bioaccumulation factor (BAF) assessments. Select a test set of chemicals which include high production volume (HPV) substances in the […]