ECO39 & 39.2: Review, ring-test and guidance for TKTD modelling
Stressors, such as toxicants, can cause mortality among organisms. Interestingly, not all individuals will die at the same time in the same exposure treatment, and the number of deaths will change with exposure time. The pattern of mortality will also […]
AIMT7: RVis – Open Access PBPK Modelling Platform
The objective of this project is to further develop RVis, a prototype application for the analysis of structure and performance of physiologically based pharmacokinetic (PBPK), and other models, written in the free, open source syntax R or C++. The overall […]
ECO37: D-BASS – Developing a Bioaccumulation Assessment Strategy for Surfactants
The general objective of this proposed research is therefore to validate the combined use of (a) measured partition coefficients, (b) in vitro intrinsic hepatic clearance rates, and (c) a recently improved bioaccumulation model for ionogenic compounds, against measured bioconcentration factors […]
ARC3: Development of The Bioaccumulation Assessment Tool (BAT Ver.1.0) to Aid in the Bioaccumulation Assessment of Organic Chemicals
This project aims to develop a user-friendly organizational framework and computational tool in the form of an Excel spreadsheet for integrating various lines of evidence in a quantitative weight of evidence (QWOE) approach to aid regulatory decision-making for bioaccumulation assessment.
ECO36: Paving the way for QIVIVE – from nominal to free to cellular concentrations in in vitro assays
The objective of this project is to bundle existing expertise to progress exposure assessment in in vitro bioassays used for high-throughput screening (HTS) in 384- and 1536-well plates and complex in vitro bioassays based on transwell and 3D cultures.
B19: Extrapolating the Applicability of Worker Exposure Measurement Data
The purpose of this project is to develop criteria and examples (case studies) that can be applied to evaluate if exposure measurements for a given substance(s) and use scenario(s) might be reasonably representative for another substance used in the same […]
AIMT8: Prediction of systemic toxicity after repeated exposure by new approach methodologies (NAMs) – is prediction of STOR-RE classification possible?
This project aims to assess the ability of currently available new approach methodologies (NAM) to predict STOT-RE categories of a range of chemicals for which both in vitro and in vivo data are available and that can be profiled in […]
ECO33: Use And Interpretation Of Dietary Bioaccumulation Tests For Hydrophobic
The overall objective of the proposed research is to improve the interpretation of dietary bioaccumulation tests for hydrophobic chemicals.
ECO35: Interference of hepatotoxicity with endocrine activity in fish
The project proposed is driven by the hypothesis that hepatotoxicity may positively or negatively interfere with vitellogenin production, which is used as a key marker of endocrine activity in current OECD test guidelines 229, 230 and 234 and the proposed […]
ECO20.2: Development of an alternative testing strategy for the fish early life-stage test for predicting chronic toxicity: assay validation
This project demonstrates the use of in chemico assays targeting specific key events of an established Adverse Outcome Pathway (AOP) to predict higher biological endpoints. One of the case studies in this project focused on the role of thyroid hormones […]