RTD-INSERM: Neuroendocrine Effects of Endocrine Active Chemicals (EAC): a Literature Review
The mammalian brain and pituitary gland (hypophysis) are clearly target organs for steroid and thyroid hormone action. There is also evidence that prenatal (in utero) or neonatal (young) exposure to high concentrations of some chemicals can affect the developing nervous […]
EMSG35-BASF: Enhanced OECD TG 407 – Development and Validation
Concerns that toxicological test guidelines may not optimally detect effects on the endocrine system have lead to proposals to enhance the current sub-acute rodent OECD Test Guideline No. 407 (OECD 1995). The efficacy of the modified enhanced (phase 2) protocol […]
EMSG27: Environmental Effects on Uterine Tissues of Baltic Seals With Special Emphasis on Organochlorines and Uterine Leiomyomas
The study investigated whether leiomyomas in grey seals, collected during the period of decreased levels of organo-chlorines, were in a regressive phase; and whether the period of increased levels of organo-chlorines caused the leiomyomas to proliferate. In addition, in vitro […]
EMSG28: Development, Validation and Application of in Vitro and in Vivo Test Systems for Non-Oestrogenic Endocrine Disrupting Chemicals in Wildlife
The project will provide information on effective in vitro (T-screen & Keratonisation Assay) and in vivo assays (metamorphosis, migration and prolonged FETAX-assay) for alterations of thyroid and retinoid dependent processes. It will bridge the gap between the in vitro and […]
EMSG8: Are Connexins, the Gap Junctional Integral Proteins, Involved in Male Reproductive Disorders Associated With Possible Exposure to Endocrine Disrupting Agents?
The objective of the project is to verify whether impairment of expression and/or function of the gap junctional connexins (elements of the gap junction structure; this structure facilitates "communication" between cells) could be implicated in human male reproductive disorders. An […]
EMSG9: Development of a Sensitive Assay for Androgenic Activity Using Prostate Cells Lines
The objective of the project is to develop an in vitro assay for androgenic activity based on the use of prostate cell lines. This involves testing and validation of the cell line LNCaP, which is sensitive to weak androgens, anti-androgens, […]
EMSG10: Do Industrial Oestrogens or Their Metabolites Influence Male Reproductive Function?
The objective of the study was to investigate if alkylphenols, which had been shown to bind to oestrogen receptors, might also influence the catabolism and bioavailablity of natural oestrogens by acting as substrates and/or inhibitors of phenolsulphotransferase activity. The results […]