ECO 41: Enhanced Screening Methods to Determine Bioaccumulation Potential of Chemicals in Air-Breathing Species
This project will develop an approach for assessing bioaccumulation of neutral hydrophobic organic chemicals in air-breathing species based on physical chemical properties (i.e. KOW and KOA) and in-vitro biotransformation bioassay data using mammalian liver S9 in vitro bioassays. This approach […]
ECO 38: Cross-validation for improving determinations of water solubility for difficult to test substances
Water solubility is a fundamental parameter for the environmental risk assessment of organic chemicals. It is critical for understanding and predicting the environmental fate of substances, and also has relevance for their effect assessment. While water solubility is relatively easy […]
ECO 40 : Investigations on the bioconcentrations of xenobiotics in the freshwater amphipod Hyalella Azteca and inter-laboratory comparison of a new BCF test protocol.
The identification and scientific assessment of compounds that bioaccumulate in organisms and biomagnify in food webs are important aspects in the regulation of chemicals in several jurisdictions, such as Regulation (EC) No 1107/2009, the Regulation on classification, labelling and packaging […]
ECO39: Review, ring-test and guidance for TKTD modelling
The additional information and insight gained through the application of toxicokinetic-toxicodynamic (TKTD) modelling can strengthen the environmental risk assessment of chemicals, such as those applied in consumer products or plant protection products (PPPs). For the endpoint survival the most suitable […]
AIMT7: RVis – Open Access PBPK Modelling Platform
The objective of this project is to further develop RVis, a prototype application for the analysis of structure and performance of physiologically based pharmacokinetic (PBPK), and other models, written in the free, open source syntax R or C++. The overall […]
ECO37: D-BASS – Developing a Bioaccumulation Assessment Strategy for Surfactants
The general objective of this proposed research is therefore to validate the combined use of (a) measured partition coefficients, (b) in vitro intrinsic hepatic clearance rates, and (c) a recently improved bioaccumulation model for ionogenic compounds, against measured bioconcentration factors […]
ARC.3: Development of The Bioaccumulation Assessment Tool (BAT Ver.1.0) to Aid in the Bioaccumulation Assessment of Organic Chemicals
This project aims to develop a user-friendly organizational framework and computational tool in the form of an Excel spreadsheet for integrating various lines of evidence in a quantitative weight of evidence (QWOE) approach to aid regulatory decision-making for bioaccumulation assessment.
ECO36: Paving the way for QIVIVE – from nominal to free to cellular concentrations in in vitro assays
The objective of this project is to bundle existing expertise to progress exposure assessment in in vitro bioassays used for high-throughput screening (HTS) in 384- and 1536-well plates and complex in vitro bioassays based on transwell and 3D cultures.
B19: Extrapolating the Applicability of Worker Exposure Measurement Data
The purpose of this project is to develop criteria and examples (case studies) that can be applied to evaluate if exposure measurements for a given substance(s) and use scenario(s) might be reasonably representative for another substance used in the same […]
AIMT 8: “Assessing New Methodology for Repeat Dose Toxicological Hazard Assessment by “Equivalent Protection”
This project aims to assess the ability of currently available new approach methodologies (NAM) to predict STOT-RE categories of a range of chemicals for which both in vitro and in vivo data are available and that can be profiled in […]