B20 – Experimental assessment of inhalation and dermal exposure to chemicals during industrial and professional activities
The purpose of this project is to generate inhalation and dermal exposure data that can be used to evaluate ECETOC TRA worker exposure estimates for key industrial and professional uses of chemicals for PROCs where in previous validation studies the […]
ECO42: Fate-directed toxicity testing and risk assessment of UVCBs
The objectives of this project are (1) to develop and test new approaches for fate-directed ecotoxicity assessment of UVCBs based on new combinations of analytical methods, dosing methods, fate directed fractionation, toxicity testing and models, (2) to conduct a case […]
ECO43: Improving sediment toxicity testing design and data interpretation for very hydrophobic substances
The general objective of the proposed research is to improve sediment toxicity testing design, performance, and data interpretation for VHOCs and to develop guidance in order to maximize realism and value of future testing and thereby to support product and […]
ECO41: Enhanced Screening Methods to Determine Bioaccumulation Potential of Chemicals in Air-Breathing Species
This project plans to develop an approach for assessing bioaccumulation of neutral hydrophobic organic chemicals in air-breathing species based on physical chemical properties (i.e. KOW and KOA) and in-vitro biotransformation bioassay data using mammalian liver S9 in vitro bioassays.
ECO45: Chemicals – Assessment of Risks to Ecosystem Services (CARES) II
This project aims to evaluate the practical applicability of an ecosystem services approach to prospective and retrospective chemical risk assessment.
C4: Transcriptomics bioinformatics best practices in toxicogenomics for regulatory application
This project proposal aims to regroup toxicogenomics experts to test and further develop a regulatory ODAF (R-ODAF) proposal for the toxicogenomics community with the ambition to enable the regulatory bodies to consider omics as a relevant data type to support […]
ECO38: Cross-validation for improving determinations of water solubility for difficult to test substances
Water solubility is a fundamental parameter for the environmental risk assessment of organic chemicals. It is critical for understanding and predicting the environmental fate of substances, and also has relevance for their effect assessment. While water solubility is relatively easy […]
ECO40: Investigations on the bioconcentrations of xenobiotics in the freshwater amphipod Hyalella Azteca and inter-laboratory comparison of a new BCF test protocol.
The identification and scientific assessment of compounds that bioaccumulate in organisms and biomagnify in food webs are important aspects in the regulation of chemicals in several jurisdictions, such as Regulation (EC) No 1107/2009, the Regulation on classification, labelling and packaging […]
ECO39: Review, ring-test and guidance for TKTD modelling
The additional information and insight gained through the application of toxicokinetic-toxicodynamic (TKTD) modelling can strengthen the environmental risk assessment of chemicals, such as those applied in consumer products or plant protection products (PPPs). For the endpoint survival the most suitable […]
AIMT7: RVis – Open Access PBPK Modelling Platform
The objective of this project is to further develop RVis, a prototype application for the analysis of structure and performance of physiologically based pharmacokinetic (PBPK), and other models, written in the free, open source syntax R or C++. The overall […]