Cefic-lri Programme | European Chemical Industry Council

Projects

ECO-46 – Improved aquatic Testing and Assessment of cationic Polymers (iTAP)

The aim of this PROJECT PROPOSAL is to collate and update the existing global knowledge base on the available methods for the assessment of cationic polymers toxicity, fate properties as well as regarding their known descriptors used to develop Structure […]

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C6 – Toxicogenomic Approaches to Support Read-Across

Read-across is an old concept that is being increasingly utilized in chemical risk assessment. The basic premise for read-across is that compounds with similar chemical structure will have the same biological activity either because they are metabolized to a common […]

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C5 – XomeTox – evaluating multi-omics integration for assessing rodent thyroid toxicity

In combining an animal toxicity study with a multi-omics approach and advanced in silico methods for data interpretation, this project will contribute to “New research tools, such as […] genomics, present exciting approaches that have the potential to link information […]

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C4 – Transcriptomics bioinformatics best practices in toxicogenomics for regulatory application

This project proposal aims to regroup toxicogenomics experts to test and further develop a regulatory ODAF (R-ODAF) proposal for the toxicogenomics community with the ambition to enable the regulatory bodies to consider omics as a relevant data type to support […]

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ECO44 – A toxicokinetic mammalian modelling framework for B assessment

The general objective of this project is to build a toxicokinetic (TK) modelling framework for mammals and develop and integrate various data streams for mammalian B assessment. This research will expand the development, evaluation, and application of the CEFIC-LRI funded […]

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B15.2: Development of an integrated risk management measure library

REACH and other European legislation require that companies demonstrate the safe use and control of hazardous substances. For this purpose, the quantitative efficiency of Risk Management Measures (RMM) is required to evaluate the operational conditions (OCs) that are part of […]

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B20 – Experimental assessment of inhalation and dermal exposure to chemicals during industrial and professional activities

The purpose of this project is to generate inhalation and dermal exposure data that can be used to evaluate ECETOC TRA worker exposure estimates for key industrial and professional uses of chemicals for PROCs where in previous validation studies the […]

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ECO42: Fate-directed toxicity testing and risk assessment of UVCBs

The objectives of this project are (1) to develop and test new approaches for fate-directed ecotoxicity assessment of UVCBs based on new combinations of analytical methods, dosing methods, fate directed fractionation, toxicity testing and models, (2) to conduct a case […]

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ECO43: Improving sediment toxicity testing design and data interpretation for very hydrophobic substances

The general objective of the proposed research is to improve sediment toxicity testing design, performance, and data interpretation for VHOCs and to develop guidance in order to maximize realism and value of future testing and thereby to support product and […]

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ECO41: Enhanced Screening Methods to Determine Bioaccumulation Potential of Chemicals in Air-Breathing Species

This project plans to develop an approach for assessing bioaccumulation of neutral hydrophobic organic chemicals in air-breathing species based on physical chemical properties (i.e. KOW and KOA) and in-vitro biotransformation bioassay data using mammalian liver S9 in vitro bioassays.

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