The objective of this investigation is to use of histopathological/morphometric techniques to assess whether or not there have been changes in morphology of the human testis over the past 50 years.
Specific DNA adducts have been shown to cause gene mutations and carcinogenesis but despite extensive work the biological significance of DNA adduct levels in human populations is largely unknown, in part because all human tissues contain DNA adducts of varying […]
The main objective of this project is to use dendritic-like cells derived from a human cell line to develop a robust in vitro system to distinguish between respiratory vs contact sensitising chemicals. Whilst the use of cell lines will help […]
The objective of the research was to determine whether the levels of binding between oestrogenic chemicals and pure oestrogen receptor could be quantified in vitro using ligand receptor interaction analysis. The hope was that such technology might be usefully applied […]
The common current assumption is that there is an essentially linear relationship between exposure to genotoxic chemicals, DNA lesion formation and the induction of mutagenic changes. A number of studies of DNA adduct induction indicate that such a linear relationship […]
Making reliable estimates of the amounts of chemicals deposited on the skin and clothing in the workplace is essential in evaluating any health risks. It also helps in assessing the effectiveness of protective equipment. There is a lack of detailed […]
Hypospadias is a male birth defect in which the urethral orifice is abnormally located on the ventral side of the penis. In western countries, the prevalence of hypospadias varies from 2 to 8 cases per 1000 live births. An increase […]
DNA adducts are biomarkers of genotoxicity, and there is an ongoing discussion whether the dose response for DNA-adduct levels also predicts the dose response for mutation or even cancer. A linear low dose-effect relationship is plausible for the rate of […]
Di-isocyanates are in many countries a major cause of occupational asthma. However, few recent studies are available in which exposure to isocyanates has been measured and related to respiratory disease risk. Thus, information about exposure response relationships is extremely limited. […]
The objective of the project was to identify biochemical endpoints of oestrogen action in the male rat during foetal and neonatal development, which may have potential for monitoring the level of "oestrogen" exposure of individual animals, either in infancy or […]
Terms and Conditions of Use | Privacy Policy | Cookie Policy | Coockie Settings
© Copyright 2017 Cefic | European Chemical Industry Council. All rights reserved.
