Projects
EMSG42: Increase of the robustness of the fish endocrine assay and avoidance of irrelevant endpoints
The objective of this study was to determine the influence of the test items potassium permanganate, 2-methoxyethanol and octanol to reproduction and the endocrine system of fathead minnow (Pimephales promelas). For this purpose, mature male and female fathead minnow were exposed in […]
21DAY: Phase 3 of the validation of the OECD Fish Screening Assay
The eight studies in the attached report were conducted as part of OECD Test Guideline program to validate a standardized OECD protocol for a 21-day fish screening assay for the detection of endocrine active substances (i.e. estrogen, aromatase inhibitors, androgen). […]
D2.2-VITO: Generation and Application of a Model to Determine Intra- and Inter-individual Variation in Biomarkers
Biomarkers which reflect levels of pollutants in the human body offer a unique opportunity to investigate impact of environmental pollution on humans. Biomarker levels in the general population are influenced by genetic, physiological and external factors. Knowledge on which factors […]
B2.2-FoBiG: Provide Examples Where Risk Characterisations can be Conducted With the Existing and Possible Inadequate Data Sets
This project will evaluate the estimates used today by several organisations (e.g. U.S.-EPA, WHO, EU) to assess the human health risks of chemical exposure, which result in the derivation of human limit values such as acceptable daily intake, reference doses […]
EEM1-ASTRA: Identification and Evaluation of Emission Databases in Europe
Estimating how much of a particular chemical is released to the environment is key to assessing likely levels of exposure and risk to humans and the environment. Such estimates are often based on very general information due to a lack […]
B2.3-IOM: Variability and Uncertainty in Chemical Exposures for Regulatory Risk Assessment
The aim of this project is to investigate how the variability and uncertainty of occupational inhalation exposure information may be better incorporated into the European regulatory risk assessment process. In this proposal, we have chosen to focus specifically on inhalation […]
EEM4: Development of Tools for Probabilistic Uncertainty Analysis in Environmental Risk Assessment of Chemicals
The risk to wildlife or the environment posed by a given chemical depends on whether its environmental concentration is greater than set quality objectives (the risk quotient). Both environmental concentrations and quality objectives are calculated based on chance (probability), a […]
B3.7-HSL: The Rapid Generation And Analysis of Physiologically-Based Pharmacokinetic Models (PBPK Model)
The widespread use and acceptance of PBPK modelling has been advocated for many years, as this technique offers a more scientific and quantitative approach to chemical risk assessment, as well as offering the opportunity of a marked reduction in the […]
EMSG7: Screening Test in Fish – Aquatic Toxicity Project A
An in vivo screening test for oestrogenicity was developed jointly by three laboratories by measuring vitellogenin in fathead minnows after up to 21 days exposure. This method will be further refined by determination of (anti-)androgens and aromatase inhibitors in the […]
