In the field of ecotoxicolgy the quantification of differences in species susceptibility to toxic substances is mainly estimated using statistical approaches. Although these approaches are very useful for use in Environmental Risk Assessment, they aim at quantifying the variation in […]
To accomplish international recognition of the RTgill-W1 cell line assay for predicting acute toxicity to fish, the project aims to initiate a round-robin trial in order to test the robustness of the established methodology. In particular, the team aims to evaluate the […]
Since the publication of the OECD AOP for skin sensitisation in 2012, there have been even greater efforts to anchor the development and evaluation of new in vitro and in chemico assays to key events within the AOP. Much of […]
Volatile organic compounds (VOCs) are ubiquitous in indoor air and their origin is a plethora of various emission sources including building related materials, furniture, equipment and consumer and household related products. Currently, there is international recognition of the contribution of […]
Environmental exposures during fetal and early life may contribute to complex disease later in life such as allergic diseases (AD), neurodegenerative diseases and cancer. The underlying mechanisms are still undiscovered, but changes in the epigenetic regulation of gene expression (such […]
ECO11: Towards rationally designed hazard, risk and persistency assessment: Putting the “bio” back into biodegradability tests The objectives of this project are as follows: Objective 1a. Determine the extent and variation in microbial diversity of environmental sources used in biodegradation […]
REACH Guidance for Chemical Safety Assessment makes use of mathematical simulation of the retention of chemical substances during waste water treatment. REACH R-16 describes the use of the model SimpleTreat, developed by Struijs and co-workers at RIVM, which simulates the […]
The main objective of this study is to map the state of the art in passive sampling sediments and to investigate which measures we can take to reduce any inter-method and -laboratory variation, in order to increase confidence in the […]
The European Chemical Industry Council has provided funding to Maastricht University for a research project on Research Integrity by exploring one of the most suspected contributors to questionable research practices: selective citation. It is generally accepted that scientific papers should […]
A major hurdle in using chemoinformatic systems is the lack of easily accessible data on substance identity including structures and composition e.g. constituents, impurities and additives as well as high quality, detailed endpoint data of chemical substances. This project is […]
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