Cefic-lri Programme | European Chemical Industry Council

Projects

ECO3A.3-USTO: Evaluation of the predictability and reversibility of environmental accumulation for substances for POP/PBT-like properties

The objectives of these project are: - to gain a quantitative understanding of how chemical and environmental characteristics interact to control long-term time trends of POP/PBT-like substances in various environmental compartments. - to test the ability of current dynamic multimedia models to […]

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ART-TNO: Phase 1: mechanistic model and Bayesian update

Under REACH, the new chemicals policy in Europe, exposure scenarios form an essential basis for chemical risk assessment reports to show that chemicals can be used safely. This requires a tiered exposure assessment approach in which the first Tier is […]

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ART.2-TNO: Advanced REACH Tool – Exposure Database development and population for version 1.5

Under REACH, the new chemicals policy in Europe, exposure scenarios form an essential basis for chemical risk assessment reports to show that chemicals can be used safely. This requires a tiered exposure assessment approach in which the first Tier is […]

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ECO9-VUA: Relationships between BCF, BMF and BAF: Improving forecasting of residues in biota in the environment based on laboratory testing

Objectives Overview   Identify the key properties and parameters impacting bioconcentration factor (BCF) measurements in the laboratory and those impacting field bioaccumulation factor (BAF) assessments. Select a test set of chemicals which include high production volume (HPV) substances in the […]

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C2.2-HPAG: Description of the nature of the accidental misuse of chemicals and chemical products

The overall objective of this research project is: - To describe the nature of accidental misuse of chemicals and chemical products available to consumers and to put this information in the context of overall estimates of accidental injury from chemicals. […]

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HBM3: Data on in vitro metabolism and mechanisms of action in combination with kinetic modelling: integrating in risk assessment

The objectives of this project are the further development of strategies making use of the integration of different areas of knowledge on the chemistry and the biological activity of compounds, and their use in the interpretation of biomonitoring data. These […]

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ECO13: Development, application and evaluation of model-based screening procedures for PBT chemicals and POPs (SCREEN-POP)

The scientific objectives of this project are: 1.To create a tiered screening system for identifying potential PBTs and POPs amongst existing chemicals; 2.To verify whether the potential PBTs / POPs identified in the screening program are present in the European background […]

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HBM2-DOW: Development of a Tiered Set of Modelling Tools for Derivation of Biomonitoring Guidance Values

Current determinations of the exposures that correspond with biomonitoring data (parent/metabolite in blood/urine) are generally conducted with chemical-specific pharmacokinetic models that are physiologically-based (PBPK), to best simulate xenobiotic disposition in complex mammalian systems. While these models are necessary to accurately […]

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HBM2.2-ITC: Development of a computer program with a multi-level modelling tool for the estimation of biomonitoring equivalent guidance values for chemical agents related to health based exposure rates for inhalation, oral intake and/or skin exposure.

Objective: Development of a tiered tool with compartmental and physiologically based toxicokinetic models, taken up in a software program, to derive Biomonitoring Equivalent Guidance Values (BEGV) based on existing health based acceptable daily doses or acceptable health based daily exposures. […]

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ECO10: EPOCH – Evaluation of existing population models for their potential application in ecological risk assessment of chemicals

The objective of the project is to provide a review of population models which can be directly used or which might be modified for the ecological risk assessment of chemicals (ERA). The main focus will be on the aquatic environment […]

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