Cefic-lri Programme | European Chemical Industry Council

Projects

CC2-UNBI: Determination of Human and Rodent Gene Expression Patterns in Response to Chemical Carcinogens: Facilitation of Knowledge-Based Human Risk Assessment From Molecular Mechanisms

Naturally-occurring and man-made chemicals are widespread in the environment. Predictions of human health risks are usually based on laboratory tests on animals such as rats and mice. Occasionally, cancer does occur in mice alone or in both rats and mice […]

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CC2-MRCT: Gene Expression Profiling of Skin Carcinogenesis in Mice Using cDNA Microarrays

Skin cancers are very common in humans - with around one million cases/year in the US - and their development can be affected by stimulators of growth such as certain chemicals. Although initiation is clearly extremely important, clonal expansion (promotion) […]

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CC2-LUMC: Gene Expression Profiling in DNA Repair-Deficient XPA Transgenic Mice Following Treatment With Benzo[A]Pyrene and Cyclosporin-A: Lymphomagens with Different Modes of Action

Many environmental chemicals which have been shown to cause cancer in rodents have been implicated in human cancer. However, establishing cause and effect in humans is often impossible. Today, the only accepted test for human carcinogenicity is the two-year rodent […]

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CC1-USTR: Interspecies Differences in the Metabolism of Toxic Aldehydes and Ketones by the AKR7 Family of Aldo-Keto Reductases

Highly reactive carbonyl compounds, aldehydes and ketones - found in a diverse range of natural and synthetic compounds - can cause cancer by damaging cell proteins and DNA. To help prevent this cells contain enzymes, which can break down these […]

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CC1-UNEW/ZENE: Molecular Toxicology and Structure Activity Relationships in the Rodent Carcinogenesis of Industrially Important Dienes and the Relevance for Human Cancer

About one-half of chemicals tested for long-term health effects in laboratory rats and mice have been found to cause cancer. The accuracy of these tests in predicting human cancer risks needs to be fully understood, particularly for chemicals produced and […]

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CC1-FOAR: Development of Criteria for Threshold Genotoxins: Interactions of Chemical Carcinogens With Cytoskeletal Macromolecules

This project will examine the ways in which chemicals that cause cancer and genetic damage interact with structural elements in human cells known as cytoskeletal proteins. Because proteins play a key role in cell division, interfering with their functioning can […]

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